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Information on EC 1.14.13.181 - 13-deoxydaunorubicin hydroxylase

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IUBMB Comments
The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
DoxA, DoxA monooxygenase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
13-deoxydaunorubicin + NADPH + H+ + O2 = 13-dihydrodaunorubicin + NADP+ + H2O
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13-dihydrodaunorubicin + NADPH + H+ + O2 = daunorubicin + NADP+ + 2 H2O
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