Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
THP-1 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IDO1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | IFN-gamma stimulates the expression of indoleamine 2,3-dioxygenase | up |
General Information | Comment | Organism |
---|---|---|
metabolism | infection of THP-1 cells with GRA15-intact Toxoplasma gondii produces IL-1beta in a manner dependent on NLRP3 and caspase-1. This leads to an indirect reduction in IDO1 proteins, thereby supporting parasite growth in human cells | Homo sapiens |
physiological function | IFN-gamma stimulates the expression of indoleamine 2,3-dioxygenase to degrade tryptophan, an essential nutritional amino acid for the intracellular growth of Toxoplasma gondii in human cells | Homo sapiens |