Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.52 extracted from

  • Yamamoto, S.; Hayaishi, O.
    Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rabbit intestine) (1970), Methods Enzymol., 17A, 434-438.
No PubMed abstract available
Search for more literature for 1.13.11.52

Activating Compound

Activating Compound Comment Organism Structure
ascorbic acid 9.2 mM required for half-maximal activity Oryctolagus cuniculus
methylene blue no activity without, half-maximal activity at 0.002 mM Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
CN-
-
 Oryctolagus cuniculus
CO
-
 Oryctolagus cuniculus
N3-
-
 Oryctolagus cuniculus
NH2OH
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 L-Trp
-
 Oryctolagus cuniculus
0.3
-
 D-Trp
-
 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme from intestine Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.234
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Trp + O2
-
 Oryctolagus cuniculus N-formyl-D-kynurenine
-
 ?
L-Trp + O2
-
 Oryctolagus cuniculus L-formylkynurenine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 L-Trp Oryctolagus cuniculus
7.5
-
 D-Trp Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Oryctolagus cuniculus