Literature summary for 1.13.11.12 extracted from

Ogawa, M.; Ishihara, T.; Isobe, Y.; Kato, T.; Kuba, K.; Imai, Y.; Uchino, Y.; Tsubota, K.; Arita, M.
Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway (2020), FASEB J., 34, 12492-12501 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P39654	cf. EC 1.13.11.33, EC 1.13.11.12	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cornea	-	Mus musculus	-
eosinophil	eosinophils are the major cell type expressing 12/15-LOX during the corneal wound healing process	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	eosinophils are the major cell type expressing 12/15-LOX during the corneal wound healing process. Eosinophils are recruited into the conjunctiva after corneal epithelium wounding, and eosinophil-deficient and/or eosinophil-specific 12/15-LOX knockout mice show delayed corneal wound healing compared with wild-type mice. A series of 12/15-LOX-derived mediators are significantly decreased in eosinophil-deficient mice and topical application of 17-hydroxydocosahexaenoic acid restores the phenotype	Mus musculus

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Release 2023.1 (January 2023)