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Literature summary for 1.1.5.3 extracted from

  • Clarke, K.J.; Porter, R.K.
    The Importance of Calcium ions for determining mitochondrial glycerol-3-phosphate dehydrogenase activity when measuring uncoupling protein 1 (UCP1) function in mitochondria isolated from brown adipose tissue (2018), Methods Mol. Biol., 1782, 325-336 .
    View publication on PubMed
Search for more literature for 1.1.5.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Rattus norvegicus 5739
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Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme (mGPDH) activity is allosterically activated by calcium. In isolated brown adipose tissue mitochondria mGPDH enzyme activity is maximal at free calcium ion concentrations in the 350 nM-1000 nM range Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sn-glycerol 3-phosphate + a quinone Rattus norvegicus the enzyme converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane glycerone phosphate + a quinol
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P35571 Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sn-glycerol 3-phosphate + a quinone
-
 Rattus norvegicus glycerone phosphate + a quinol
-
 ?
sn-glycerol 3-phosphate + a quinone the enzyme converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane Rattus norvegicus glycerone phosphate + a quinol
-
 ?

Synonyms

Synonyms Comment Organism
FAD-linked glycerol-3-phosphate dehydrogenase
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 Rattus norvegicus
mGPDH
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane Rattus norvegicus