Information on EC - glycerol-3-phosphate dehydrogenase

for references in articles please use BRENDA:EC1.1.5.3
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This flavin-dependent dehydrogenase is an essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis. In bacteria, the enzyme is localized to the cytoplasmic membrane , while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane . In eukaryotes, this enzyme, together with the cytosolic enzyme EC, glycerol-3-phosphate dehydrogenase (NAD+), forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD+ by the mitochondrial electron-transport chain . This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix [7,8]. Insect flight muscle uses only CoQ10 as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ9 . The enzyme is activated by calcium .
Specify your search results
Select one or more organisms in this record: ?
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
DsFAD-GPDH, FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-G3PDH, FAD-glycerol phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol-3-phosphate dehydrogenase, flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate ubiquinone oxidoreductase, flavoprotein-dependent glycerol-3-phosphate dehydrogenase, G3PD, more
sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol
show the reaction diagram
Select items on the left to see more content.