Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CoA | mevaldehyde reduction | Pseudomonas mevalonii | |
pantetheine | mevaldehyde reduction | Pseudomonas mevalonii |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Pseudomonas mevalonii |
General Stability | Organism |
---|---|
20 mM N-ethylmaleimide, 50 min, 12% activity | Pseudomonas mevalonii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
CoASH | oxidative acylation of mevalonate | Pseudomonas mevalonii | |
0.17 | - |
NADH | reductive deacylation to mevalonate | Pseudomonas mevalonii | |
0.17 | - |
NAD+ | mevaldate oxidation | Pseudomonas mevalonii | |
0.22 | - |
mevalonate | oxidative acylation of mevalonate | Pseudomonas mevalonii | |
0.3 | - |
DL-3-hydroxy-3-methylglutaryl-CoA | reductive deacylation to mevalonate | Pseudomonas mevalonii | |
0.37 | - |
NAD+ | oxidative acylation of mevalonate | Pseudomonas mevalonii | |
1.36 | - |
DL-mevaldate | mevaldate oxidation | Pseudomonas mevalonii | |
36 | - |
DL-mevaldate | mevaldate reduction to mevalonate | Pseudomonas mevalonii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Pseudomonas mevalonii | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas mevalonii | - |
formerly Pseudomonas sp. M | - |
Purification (Comment) | Organism |
---|---|
- |
Pseudomonas mevalonii |
Storage Stability | Organism |
---|---|
-180°C, 400 mM KCl, 12 months | Pseudomonas mevalonii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ | - |
Pseudomonas mevalonii | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
r | |
3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | - |
Pseudomonas mevalonii | mevalonate + CoA + NAD+ | - |
? | |
DL-mevaldate + CoA + NAD+ | - |
Pseudomonas mevalonii | 3-hydroxy-3-methylglutaryl-CoA NADH + H+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas mevalonii | |
NADH | reverse reaction | Pseudomonas mevalonii |