BRENDA - Reference to 1.1.1.315; Id = 715451

microsome

-

Bos taurus

-

32000

-

x * 32000, SDS-PAGE

Bos taurus

11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+

Bos taurus

-

11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+

-

?

11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+

Bos taurus

-

11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+

-

?

additional information

Bos taurus

cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR

?

-

Bos taurus

-

enzyme copurifies with retinal G protein coupled receptor from microsomes

Bos taurus

retina

-

Bos taurus

-

retinal pigment epithelium

-

Bos taurus

-

11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+

-

715451

Bos taurus

11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+

-

?

11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+

-

715451

Bos taurus

11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+

-

?

additional information

cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR

715451

Bos taurus

?

-

?

x * 32000, SDS-PAGE

Bos taurus

More

enzyme copurifies with retinal G protein coupled receptor from microsomes

Bos taurus

cRDH

-

Bos taurus

NAD+

NAD+ is preferred over NADP+

Bos taurus

NADP+

NAD+ is preferred over NADP+

Bos taurus

NAD+

NAD+ is preferred over NADP+

Bos taurus

NADP+

NAD+ is preferred over NADP+

Bos taurus

microsome

-

Bos taurus

-

32000

-

x * 32000, SDS-PAGE

Bos taurus

11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+

Bos taurus

-

11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+

-

?

11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+

Bos taurus

-

11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+

-

?

additional information

Bos taurus

cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR

?

-

enzyme copurifies with retinal G protein coupled receptor from microsomes

Bos taurus

retina

-

Bos taurus

-

retinal pigment epithelium

-

Bos taurus

-

11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+

-

715451

Bos taurus

11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+

-

?

11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+

-

715451

Bos taurus

11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+

-

?

additional information

cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR

715451

Bos taurus

?

-

?

x * 32000, SDS-PAGE

Bos taurus

More

enzyme copurifies with retinal G protein coupled receptor from microsomes

Bos taurus

physiological function

cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle

Bos taurus

physiological function

cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle

Bos taurus

740740

Sahu

Conditional ablation of retino ...

Homo sapiens, Mus musculus

J. Biol. Chem.

290

27239-27247

2015

-

2

-

2

-

3

-

3

-

2

-

4

-

2

4

-

3

-

3

-

1

-

724922

Parker

Retinol dehydrogenases (RDHs) ...

Mus musculus

Exp. Eye Res.

91

788-792

2010

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

3

-

690842

Takahashi

Characterization of key residu ...

Homo sapiens

Biochem. J.

419

113-122

2009

-

1

-

13

-

8

1

-

1

-

2

-

2

-

4

-

1

4

-

13

-

8

1

-

2

-

692705

Farjo

RDH10 has 11-cis-retinol dehyd ...

Bos taurus, Homo sapiens

Invest. Ophthalmol. Vis. Sci.

50

5089-5097

2009

1

-

1

-

2

-

2

-

5

-

1

-

6

1

4

-

2

-

1

-

1

2

-

2

-

2

-

1

-

6

1

-

1

-

687735

Belyaeva

Kinetic analysis of human enzy ...

Homo sapiens

J. Biol. Chem.

283

20299-20308

2008

-

1

-

3

6

-

1

-

2

-

1

-

1

9

1

2

-

2

-

2

3

-

3

-

9

-

1

-

1

-

1

9

1

-

692332

Picozzi

Genomic organization and trans ...

Homo sapiens

FEBS Lett.

554

59-66

2003

-

1

-

9

-

2

-

9

-

715461

Wu

Mapping the ligand binding poc ...

Homo sapiens

J. Biol. Chem.

278

12390-12396

2003

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

692700

Wu

Cloning and characterization o ...

Bos taurus, Homo sapiens, Mus musculus

Invest. Ophthalmol. Vis. Sci.

43

3365-3372

2002

-

3

-

3

-

2

-

6

-

9

-

9

1

6

-

12

-

1

-

3

12

-

3

-

2

-

9

-

9

1

-

1

-

715451

Chen

Interaction of 11-cis-retinol ...

Bos taurus

J. Biol. Chem.

276

21098-21104

2001

-

1

-

1

3

-

2

-

1

-

2

-

3

2

1

-

2

-

2

-

1

-

1

3

-

1

-

2

-

3

2

-

1

-

715455

Liden

Biochemical defects in 11-cis- ...

Homo sapiens

J. Biol. Chem.

276

49251-49257

2001

-

1

11

-

1

-

2

-

2

-

1

-

1

-

1

11

-

1

-

2

-

1

-

716054

Huang

Modulation of the androgenic r ...

Homo sapiens

J. Steroid Biochem. Mol. Biol.

77

129-133

2001

-

1

-

1

-

1

-

1

-

1

-

1

-

690797

Wang

Activity of human 11-cis-retin ...

Homo sapiens

Biochem. J.

338

23-27

1999

-

1

-

3

-

2

-

3

-

45

-

8

-

2

-

1

-

2

1

-

3

-

2

-

49

-

8

-

715709

Simon

Intracellular localization and ...

Bos taurus

J. Cell Sci.

112

549-558

1999

-

2

-

1

-

1

-

1

-

2

-

1

-

1

-

716292

Gonzalez-Fernandez

-

11-cis Retinol dehydrogenase m ...

Homo sapiens

Mol. Vis.

5

XI-XII

1999

-

1

-

1

-

1

-

716309

Yamamoto

Mutations in the gene encoding ...

Homo sapiens

Nat. Genet.

22

188-191

1999

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

170681

Mata

Distribution of 11-cis LRAT, 1 ...

Bos taurus

Biochim. Biophys. Acta

1394

16-22

1998

-

4

-

2

-

2

-

1

-

4

-

2

-

692942

Su

cDNA cloning, tissue distribut ...

Mus musculus

J. Biol. Chem.

273

17910-17916

1998

-

1

-

1

-

2

-

2

-

6

-

2

-

2

-

1

2

-

1

-

2

-

6

-

692939

Chai

cDNA cloning and characterizat ...

Mus musculus

J. Biol. Chem.

272

33125-33131

1997

-

1

-

1

-

1

-

2

-

5

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

5

-

3

-

714012

Tsigelny

Structures important in NAD(P) ...

Bos taurus

Biochem. Biophys. Res. Commun.

226

118-127

1996

-

1

-

1

-

1

-

1

-

715421

Simon

The retinal pigment epithelial ...

Bos taurus

J. Biol. Chem.

270

1107-1112

1995

-

1

-

1

-

1

-

1

-

1

-

1

-

1

2

-

2

-

1

2

-

1

-

1

-

1

-

1

-

1

2

-

Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal G protein-coupled receptor opsin

Data extracted from this reference: