Application | Comment | Organism |
---|---|---|
medicine | mice infected with PGFS overexpressing parasites show an early parasitemia peak and higher heart muscle parasitic load | Trypanosoma cruzi |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Trypanosoma cruzi | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | V5BT91 | - |
- |
Trypanosoma cruzi Dm28c | V5BT91 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Trypanosoma cruzi | - |
epimastigote | - |
Trypanosoma cruzi | - |
Synonyms | Comment | Organism |
---|---|---|
TCDM_00059 | - |
Trypanosoma cruzi |
General Information | Comment | Organism |
---|---|---|
physiological function | PGFS overexpressing parasites are less able to complete the infective cycle in cell culture infections and increase cardiac tissue parasitic load in infected mice. Parasites overexpressing the enzyme increase PGF2alpha synthesis from arachidonic acid and display increased susceptibility to benznidazole and nifurtimox but increased resistance to hydrogen peroxide | Trypanosoma cruzi |