Cloned (Comment) | Organism |
---|---|
expressed in MA-10 cells | Homo sapiens |
gene HSD3B2, analysis of expression and its regulation involving Nur77 factors in H295R and MA-10 cell lines, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DELTA5-3beta-hydroxysteroid + NAD+ | Homo sapiens | the enzyme is essential for biosynthesis of all classes of steroid hormones, molecular mechanisms of enzyme regulation involving the Nur77 family of immediate-early orphan nuclear receptors, e.g. Nur77 targets the promoter of gene HSD3B2 in testicular Leygig cells, overview | DELTA4-3-oxosteroid + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
type 2 isozyme, gene HSD3B2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
gonad | - |
Homo sapiens | - |
H295R cell | adrenal cell line | Homo sapiens | - |
Leydig cell | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DELTA5-3beta-hydroxysteroid + NAD+ | the enzyme is essential for biosynthesis of all classes of steroid hormones, molecular mechanisms of enzyme regulation involving the Nur77 family of immediate-early orphan nuclear receptors, e.g. Nur77 targets the promoter of gene HSD3B2 in testicular Leygig cells, overview | Homo sapiens | DELTA4-3-oxosteroid + NADH + H+ | - |
? | |
DELTA5-3beta-hydroxysteroid + NAD+ | the enzyme performs the 3beta-hydroxysteroid dehydrogenase and DELTA5-DELTA4 isomerase reactions | Homo sapiens | DELTA4-3-oxosteroid + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-HSD2 | - |
Homo sapiens |
3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |