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Disease on EC 7.6.2.16 - ABC-type putrescine transporter

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
abc-type putrescine transporter deficiency
Dermal Fibroblast SLC3A2 Deficiency Leads to Premature Aging and Loss of Epithelial Homeostasis.
Adenocarcinoma of Lung
Targeting SLC3A2 subunit of system XC- is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma.
Asthma
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
Breast Neoplasms
xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers.
Carcinoma
SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer.
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
Carcinoma, Hepatocellular
IFN?-mediated repression of system xc- drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells.
Loss of intracellular putrescine pool-size regulation induces apoptosis.
Carcinoma, Squamous Cell
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
Colonic Neoplasms
Identification and characterization of a diamine exporter in colon epithelial cells.
Infections
Feature Article: Evidence for additive and interaction effects of host genotype and infection in malaria.
Lung Neoplasms
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.
Mouth Neoplasms
Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients.
Neoplasms
18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy.
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.
Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.
HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2.
Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.
Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients.
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.
SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer.
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
Targeting SLC3A2 subunit of system XC- is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma.
The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes.
ZEB1 Promotes Chemoresistance to Cisplatin in Ovarian Cancer Cells by Suppressing SLC3A2.
Neuroblastoma
Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin.
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.
Osteosarcoma
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.
Ovarian Neoplasms
ZEB1 Promotes Chemoresistance to Cisplatin in Ovarian Cancer Cells by Suppressing SLC3A2.
Prostatic Neoplasms
Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer.
Squamous Cell Carcinoma of Head and Neck
Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy.
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
Stomach Neoplasms
Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.
SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer.
Syphilis
Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor.