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Information on EC 6.3.5.8 - aminodeoxychorismate synthase
for references in articles please use BRENDA:EC6.3.5.8
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Please check here for current data: EC 2.6.1.85
Please check here for current data: EC 2.6.1.85
transferred to EC 2.6.1.85
EC Tree 6 Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.8 aminodeoxychorismate synthase
IUBMB Comments
The enzyme is composed of two parts, PabA and PabB. In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+). PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form p-aminobenzoate.
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