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Information on EC 2.6.1.85 - aminodeoxychorismate synthase

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.85 aminodeoxychorismate synthase
IUBMB Comments
The enzyme is composed of two parts, PabA and PabB. In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+). PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
4-amino-4-deoxychorismate synthase, ADC, ADC synthase, ADCS, aminodeoxychorismate synthase, PabA, PabAB, PabB, PhzE, PvADCS, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
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