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Information on EC 6.3.4.11 - biotin-[methylcrotonoyl-CoA-carboxylase] ligase for references in articles please use BRENDA:EC6.3.4.11
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EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
Beta-methylcrotonyl coenzyme A holocarboxylase synthetase, Biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, Biotin-[methylcrotonyl-CoA-carboxylase] synthetase, Synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase,
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Beta-methylcrotonyl coenzyme A holocarboxylase synthetase
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Biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase
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Biotin-[methylcrotonyl-CoA-carboxylase] synthetase
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Synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase
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ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
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ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
the first reaction step is the reversible formation of biotinyl adenylate, the biotin residue is transferred to the apoenzyme in a second step
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ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
the first reaction step is the reversible formation of biotinyl adenylate, the biotin residue is transferred to the apoenzyme in a second step
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biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
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ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
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biotin is transferred specifically to the epsilon-amino groups of lysine residues located in apocenters
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ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
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biotin is transferred specifically to the epsilon-amino groups of lysine residues located in apocenters
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ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
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additional information
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7.4 - 8.5
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85% of maximal activity at pH 7.4 and 8.5
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IVS-W
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IVS-W
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BPL1_HUMAN
726
0
80760
Swiss-Prot
BPL1_MOUSE
722
0
78516
Swiss-Prot
BPL1_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
631
0
70632
Swiss-Prot
BPL1_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
690
0
76363
Swiss-Prot
HCS1_ARATH
367
0
41219
Swiss-Prot
A0A0F6U603_MICAE
239
0
26160
TrEMBL
A0A0J9E4V0_9RHOB
248
0
26520
TrEMBL
A0A5M3YG73_9NOCA
290
0
30987
TrEMBL
A0A385AME3_9ACTN
291
0
30517
TrEMBL
A0A0J9GSQ1_9RHOB
235
0
24840
TrEMBL
A0A5E5QGU5_9GAMM
249
0
28091
TrEMBL
C1L4U5_SCHJA
317
0
36024
TrEMBL
C1LG79_SCHJA
Blood fluke
511
0
57965
TrEMBL
C1LG79_SCHJA
511
0
57965
TrEMBL
A0A0N9ZRH2_9RHOB
250
0
26872
TrEMBL
A0A1W7M9J4_9SPHN
243
0
25646
TrEMBL
A0A0B2PN94_GLYSO
361
0
40169
TrEMBL
A0A2L2XNL1_9CHRO
239
0
26218
TrEMBL
A0A1E4QL51_MICAE
288
0
31910
TrEMBL
A0A4R6DA37_HAEHA
301
0
34041
TrEMBL
A0A151R9P7_CAJCA
156
0
16933
TrEMBL
A0A5E5PYD0_9GAMM
249
0
27833
TrEMBL
A0A5B7CAP4_DAVIN
388
0
43638
TrEMBL
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-16°C, stable for several months
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Höpner, T.; Knappe, J.
Einbau von Biotin in beta-Methylcrotonyl-CoA-carboxylase durch Holocarboxylase-synthetase
Biochem. Z.
342
190-206
1965
Achromobacter sp., Achromobacter sp. IVS-W, Propionibacterium freudenreichii subsp. shermanii
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6.3.4.11 biotin-[methylcrotonoyl-CoA-carboxylase] ligase
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