We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
Beta-methylcrotonyl coenzyme A holocarboxylase synthetase, Biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, Biotin-[methylcrotonyl-CoA-carboxylase] synthetase, Synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Beta-methylcrotonyl coenzyme A holocarboxylase synthetase
-
-
-
-
Biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase
-
-
-
-
Biotin-[methylcrotonyl-CoA-carboxylase] synthetase
-
-
-
-
Synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
the first reaction step is the reversible formation of biotinyl adenylate, the biotin residue is transferred to the apoenzyme in a second step
-
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
the first reaction step is the reversible formation of biotinyl adenylate, the biotin residue is transferred to the apoenzyme in a second step
-
-
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
-
biotin is transferred specifically to the epsilon-amino groups of lysine residues located in apocenters
-
?
ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
-
biotin is transferred specifically to the epsilon-amino groups of lysine residues located in apocenters
-
?
ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7.4 - 8.5
-
85% of maximal activity at pH 7.4 and 8.5
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
IVS-W
-
-
brenda
IVS-W
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
HCS1_ARATH
367
0
41219
Swiss-Prot
-
BPL1_HUMAN
726
0
80760
Swiss-Prot
-
BPL1_MOUSE
722
0
78516
Swiss-Prot
other Location (Reliability: 3 )
BPL1_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
631
0
70632
Swiss-Prot
other Location (Reliability: 3 )
BPL1_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
690
0
76363
Swiss-Prot
-
A0A6M5Z0U5_9BACT
278
0
29875
TrEMBL
other Location (Reliability: 1 )
A0A6J8BFL4_MYTCO
780
0
86813
TrEMBL
-
A0A0F6U603_MICAE
239
0
26160
TrEMBL
-
A0A5B7CAP4_DAVIN
388
0
43638
TrEMBL
-
A0A6J4STG8_9ACTN
246
0
25707
TrEMBL
-
A0A6J4SZG9_9SPHN
188
0
19978
TrEMBL
other Location (Reliability: 4 )
A0A151R9P7_CAJCA
156
0
16933
TrEMBL
-
A0A6J4UG10_9CHLR
248
0
25821
TrEMBL
-
A0A2L2XNL1_9CHRO
239
0
26218
TrEMBL
-
A0A6J8EAC8_MYTCO
272
0
29754
TrEMBL
-
A0A0B2PN94_GLYSO
361
0
40169
TrEMBL
-
C1L4U5_SCHJA
317
0
36024
TrEMBL
-
A0A5E5PYD0_9GAMM
249
0
27833
TrEMBL
-
A0A6J8BDG3_MYTCO
177
0
20298
TrEMBL
-
A0A0J9GSQ1_9RHOB
235
0
24840
TrEMBL
-
A0A5E5QGU5_9GAMM
249
0
28091
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A7H5P4U3_9CHLA
184
0
20308
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A6J4VGN8_9CHLR
278
0
29483
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A7H5P3T7_9CHLA
257
0
28480
TrEMBL
-
A0A1E4QL51_MICAE
288
0
31910
TrEMBL
-
C1LG79_SCHJA
511
0
57965
TrEMBL
-
A0A6J4N009_9ACTN
uncultured Nocardioides sp
238
0
24929
TrEMBL
Mitochondrion (Reliability: 2 )
A0A6J4T5T6_9SPHN
233
0
25856
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A6J4KDV7_9BACT
269
0
29040
TrEMBL
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-16°C, stable for several months
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Höpner, T.; Knappe, J.
Einbau von Biotin in beta-Methylcrotonyl-CoA-carboxylase durch Holocarboxylase-synthetase
Biochem. Z.
342
190-206
1965
Achromobacter sp., Propionibacterium freudenreichii subsp. shermanii, Achromobacter sp. IVS-W
brenda
Select items on the left to see more content.