Ligand biotin

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Basic Ligand Information

Molecular Structure
Picture of biotin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H16N2O3S
biotin
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Synonyms:
(+)-biotin, D-(+)-biotin, d-biotin


Show all pahtways known for Show all BRENDA pathways known for biotin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (88 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + biotin + CoA = ?
show the reaction diagram
-
ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
biocytin + H2O = biotin + L-lysine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (372 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + lipoate + biotin = AMP + diphosphate + ?
show the reaction diagram
-
ATP + biotin + apo-[3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonyl-CoA:carbondioxide ligase (ADP-forming)]
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[T26 protein]-L-glutamine + 5-(biotinamido)-pentylamine = [T26 protein]-N5-pentyl-L-glutamine + biotin
show the reaction diagram
-
-
ATP + diaminobiotin + CO2 = ADP + phosphate + biotin
show the reaction diagram
-

Enzyme Cofactor/Cosubstrate (165 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
binds possibly to beta subunit
-
enzyme contains biotin
-

Activator in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates
-
biotin-dependent enzyme
dependent on
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
above 300 mM, noncompetitive substrate inhibitor

3D Structure of Enzyme-Ligand-Complex (PDB) (21 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (24 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (70 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID

References & Links

Links to other databases for biotin

ChEBI
PubChem
ChEBI
PubChem