Reference on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming) and Organism(s) Mycobacterium tuberculosis and UniProt Accession P9WIL5
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zheng, R.; Blanchard, J.S.
Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase
Biochemistry
40
12904-12912
2001
Mycobacterium tuberculosis
Williams, L.; Zheng, R.; Blanchard, J.S.; Raushel, F.M.
Positionoal isotope exchange analysis of the pantothenate synthetase reaction
Biochemistry
42
5108-5113
2003
Mycobacterium tuberculosis
Wang, S.; Eisenberg, D.
Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
Protein Sci.
12
1097-1108
2003
Mycobacterium tuberculosis
Zheng, R.; Dam, T.K.; Brewer, C.F.; Blanchard, J.S.
Active site residues in Mycobacterium tuberculosis pantothenate synthetase required in the formation and stabilization of the adenylate intermediate
Biochemistry
43
7171-7178
2004
Mycobacterium tuberculosis
Wang, S.; Eisenberg, D.
Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action
Biochemistry
45
1554-1561
2006
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
White, E.L.; Southworth, K.; Ross, L.; Cooley, S.; Gill, R.B.; Sosa, M.I.; Manouvakhova, A.; Rasmussen, L.; Goulding, C.; Eisenberg, D.; Fletcher, T.M.
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase
J. Biomol. Screen.
12
100-105
2007
Mycobacterium tuberculosis
Velaparthi, S.; Brunsteiner, M.; Uddin, R.; Wan, B.; Franzblau, S.G.; Petukhov, P.A.
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs
J. Med. Chem.
51
1999-2002
2008
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Sledz, P.; Silvestre, H.L.; Hung, A.W.; Ciulli, A.; Blundell, T.L.; Abell, C.
Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase
J. Am. Chem. Soc.
132
4544-4545
2010
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Yang, Y.; Gao, P.; Liu, Y.; Ji, X.; Gan, M.; Guan, Y.; Hao, X.; Li, Z.; Xiao, C.
A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition
Bioorg. Med. Chem. Lett.
21
3943-3946
2011
Mycobacterium tuberculosis
Tan, Y.S.; Fuentes, G.; Verma, C.
A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: computational studies
Proteins
79
1715-1727
2011
Escherichia coli, Mycobacterium tuberculosis
Samala, G.; Devi, P.; Nallangi, R.; Sridevi, J.; Saxena, S.; Yogeeswari, P.; Sriram, D.
Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads
Bioorg. Med. Chem.
22
1938-1947
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Samala, G.; Devi, P.B.; Nallangi, R.; Yogeeswari, P.; Sriram, D.
Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors
Eur. J. Med. Chem.
69
356-364
2013
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Kumar, A.; Casey, A.; Odingo, J.; Kesicki, E.A.; Abrahams, G.; Vieth, M.; Masquelin, T.; Mizrahi, V.; Hipskind, P.A.; Sherman, D.R.; Parish, T.
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis
PLoS ONE
8
e72786
2013
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIL5)
Samala, G.; Nallangi, R.; Devi, P.B.; Saxena, S.; Yadav, R.; Sridevi, J.P.; Yogeeswari, P.; Sriram, D.
Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors
Bioorg. Med. Chem.
22
4223-4232
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv (P9WIL5)
Samala, G.; Devi, P.B.; Saxena, S.; Meda, N.; Yogeeswari, P.; Sriram, D.
Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors
Bioorg. Med. Chem.
24
1298-1307
2016
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv (P9WIL5)
Hung, A.W.; Silvestre, H.L.; Wen, S.; George, G.P.; Boland, J.; Blundell, T.L.; Ciulli, A.; Abell, C.
Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis
ChemMedChem
11
38-42
2016
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
Devi, P.B.; Samala, G.; Sridevi, J.P.; Saxena, S.; Alvala, M.; Salina, E.G.; Sriram, D.; Yogeeswari, P.
Structure-guided design of thiazolidine derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors
ChemMedChem
9
2538-2547
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv (P9WIL5)
Ntie-Kang, F.; Kannan, S.; Wichapong, K.; Owono Owono, L.; Sippl, W.; Megnassan, E.
Binding of pyrazole-based inhibitors to Mycobacterium tuberculosis pantothenate synthetase docking and MM-GB(PB)SA analysis
Mol. Biosyst.
10
223-239
2014
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
Devi, P.B.; Jogula, S.; Reddy, A.P.; Saxena, S.; Sridevi, J.P.; Sriram, D.; Yogeeswari, P.
Design of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors virtual screening, synthesis and in vitro biological activities
Mol. Inform.
34
147-159
2015
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
Pandey, B.; Grover, S.; Goyal, S.; Kumari, A.; Singh, A.; Jamal, S.; Kaur, J.; Grover, A.
Alanine mutation of the catalytic sites of pantothenate synthetase causes distinct conformational changes in the ATP binding region
Sci. Rep.
8
903
2018
Mycobacterium tuberculosis (P9WIL5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WIL5)
