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Information on EC 6.2.1.50 - 4-hydroxybenzoate adenylyltransferase FadD22

for references in articles please use BRENDA:EC6.2.1.50

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IUBMB Comments

This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate‘s activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.

The expected taxonomic range for this enzyme is: Mycobacteriaceae
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
holo-[4-hydroxyphenylalkanoate synthase]
=
+
+
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]

Synonyms
fadd22, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
show the reaction diagram
(1b)
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-
-
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
show the reaction diagram
overall reaction
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-
-
ATP + 4-hydroxybenzoate = 4-hydroxybenzoyl-adenylate + diphosphate
show the reaction diagram
(1a)
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-
-
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