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Literature summary for 6.2.1.50 extracted from

  • Simeone, R; Léger, M.; Constant, P.; Malaga, W.; Marrakchi, H.; Daffé, M.; Guilhot, C.; Chalut, C.
    Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis (2010), FEBS J., 277, 2715-2725 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] Mycobacterium tuberculosis
-
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] Mycobacterium tuberculosis H37Rv
-
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
ATP + 4-hydroxybenzoate Mycobacterium tuberculosis
-
4-hydroxybenzoyl-adenylate + diphosphate
-
?
ATP + 4-hydroxybenzoate Mycobacterium tuberculosis H37Rv
-
4-hydroxybenzoyl-adenylate + diphosphate
-
?
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] Mycobacterium tuberculosis
-
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] Mycobacterium tuberculosis H37Rv
-
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
additional information Mycobacterium tuberculosis FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate ?
-
?
additional information Mycobacterium tuberculosis H37Rv FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate ?
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQ61
-
-
Mycobacterium tuberculosis H37Rv P9WQ61
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
-
Mycobacterium tuberculosis AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase]
-
Mycobacterium tuberculosis H37Rv AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
ATP + 4-hydroxybenzoate
-
Mycobacterium tuberculosis 4-hydroxybenzoyl-adenylate + diphosphate
-
?
ATP + 4-hydroxybenzoate
-
Mycobacterium tuberculosis H37Rv 4-hydroxybenzoyl-adenylate + diphosphate
-
?
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
-
Mycobacterium tuberculosis AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase]
-
Mycobacterium tuberculosis H37Rv AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
-
?
additional information FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate Mycobacterium tuberculosis ?
-
?
additional information FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate Mycobacterium tuberculosis H37Rv ?
-
?

Synonyms

Synonyms Comment Organism
fadD22
-
Mycobacterium tuberculosis
p-hydroxybenzoic acid-AMP ligase
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function disruption of FadD22 abolishes the production of its species-specific phenolic glycolipid Mycobacterium tuberculosis