Information on EC 6.2.1.42 - 3-oxocholest-4-en-26-oate-CoA ligase

for references in articles please use BRENDA:EC6.2.1.42
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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.42 3-oxocholest-4-en-26-oate-CoA ligase
IUBMB Comments
The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3beta-hydroxycholest-5-en-26-oate can also be used as substrate.
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The enzyme appears in viruses and cellular organisms
Synonyms
fadD19, steroid-CoA ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (25S)-3-oxocholest-4-en-26-oate + CoA = AMP + diphosphate + (25S)-3-oxocholest-4-en-26-oyl-CoA
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