Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 6.1.1.6 - lysine-tRNA ligase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis, Lactic
Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.
Carcinogenesis
Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.
Carcinoma
Correction: Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Lysyl-tRNA Synthetase (KRS) Expression in Gastric Carcinoma and Tumor-Associated Inflammation.
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Correction: Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Cardiomyopathies
Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.
Charcot-Marie-Tooth Disease
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes.
Colonic Neoplasms
Erratum: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
Plasma Lysyl-tRNA Synthetase 1 (KARS1) as a Novel Diagnostic and Monitoring Biomarker for Colorectal Cancer.
Colorectal Neoplasms
Plasma Lysyl-tRNA Synthetase 1 (KARS1) as a Novel Diagnostic and Monitoring Biomarker for Colorectal Cancer.
Cryptosporidiosis
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Deafness
Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.
Hearing Loss
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes.
Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89.
Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.
Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment.
Infections
HIV-1 exploits dynamic multi-aminoacyl-tRNA synthetase complex to enhance viral replication.
Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent.
Influenza, Human
High-yield soluble expression of recombinant influenza virus antigens from Escherichia coli and their potential uses in diagnosis.
Leukoencephalopathies
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes.
Liver Failure
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Loiasis
Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis.
Lung Neoplasms
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Lyme Disease
Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi.
Differentiation of Borrelia burgdorferi sensu lato strains using class I lysyl-tRNA synthetase-encoding genes.
Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code.
Transfer RNA recognition by class I lysyl-tRNA synthetase from the Lyme disease pathogen Borrelia burgdorferi.
Lymphatic Metastasis
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Lymphoma
Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor.
Malaria
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Side chain rotameric changes and backbone dynamics enable specific cladosporin binding in Plasmodium falciparum lysyl-tRNA synthetase.
Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development.
Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin.
Microcephaly
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes.
Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.
Microphthalmos
Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells.
Mutation in KARS: A novel mechanism for severe anaphylaxis.
Nonconventional involvement of LysRS in the molecular mechanism of USF2 transcriptional activity in FcepsilonRI-activated mast cells.
Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex.
Myocardial Ischemia
[Seasonal differences in activity of tRNA and aminoacyl-tRNA synthetases of rabbit liver in myocardial ischemia]
Neoplasm Metastasis
Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR.
Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis.
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell?extracellular matrix adhesion for migration.
Neoplasms
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.
Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR.
Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis.
Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.
Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration.
KRS: A cut away from release in exosomes.
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell?extracellular matrix adhesion for migration.
The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer.
Osteosarcoma
Nuclear localization of aminoacyl-tRNA synthetases using single-cell capillary electrophoresis laser-induced fluorescence analysis.
Peripheral Nervous System Diseases
Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy.
Polyneuropathies
Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.
Schistosomiasis
Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis.
Starvation
Exosomal secretion of truncated cytosolic lysyl-tRNA synthetase induces inflammation during cell starvation.
Syphilis
Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum.
Tuberculosis
Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis.
Vision Disorders
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes.
Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.