Disease on EC 6.1.1.15 - proline-tRNA ligase
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Aneurysm
Validation of the Simbionix PROcedure Rehearsal Studio sizing module: A comparison of software for endovascular aneurysm repair sizing and planning.
Carcinogenesis
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
Coccidiosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Coinfection
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
Cryptosporidiosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Dengue
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
Diffuse Cerebral Sclerosis of Schilder
The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.
Diffuse Cerebral Sclerosis of Schilder
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
Gastroenteritis
Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3' end of the transmissible gastroenteritis coronavirus genome modulating innate immune response.
Idiopathic Pulmonary Fibrosis
Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis.
Intestinal Volvulus
Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths.
Leishmaniasis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Malaria
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Malaria
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
Malaria
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Malaria
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Neoplasms
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
Neoplasms
EPRS/GluRS promotes gastric cancer development via WNT/GSK-3?/?-catenin signaling pathway.
Neoplasms
Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue.
Neoplasms
The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens.
Neurodegenerative Diseases
The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.
Starvation
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.
Toxoplasmosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Virus Diseases
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.
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