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Information on EC 6.1.1.11 - serine-tRNA ligase and Organism(s) Danio rerio and UniProt Accession Q6DRC0

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EC Tree
IUBMB Comments
This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.
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This record set is specific for:
Danio rerio
UNIPROT: Q6DRC0
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
serrs, seryl-trna synthetase, seryl trna synthetase, mtserrs, serrs2, mmbserrs, seryl-trna-synthetase, serzmo, methanogenic-type serrs, serrs1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Seryl-tRNA synthetase
-
62 kDa RNA-binding protein
-
-
-
-
Serine transfer RNA synthetase
-
-
-
-
Serine translase
-
-
-
-
Serine--tRNA ligase
-
-
-
-
SerRS
-
-
-
-
SerRSmt
-
-
-
-
SERSEC
-
-
-
-
Seryl-transfer ribonucleate synthetase
-
-
-
-
Seryl-transfer ribonucleic acid synthetase
-
-
-
-
Seryl-transfer RNA synthetase
Seryl-tRNA synthetase
Synthetase, seryl-transfer ribonucleate
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Aminoacylation
-
esterification
-
-
-
-
Aminoacylation
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
L-serine:tRNASer ligase (AMP-forming)
This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-48-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
-
-
-
?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
-
-
-
?
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
aminoacylation assay
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
aminoacylation assay at room temperature
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
seryl-tRNA synthetase is involved in vascular development
malfunction
-
impairment of zygotic Sars function leads to a significant dilatation of the aortic arch vessels and aberrant branching of cranial and intersegmental vessels
physiological function
-
seryl-tRNA synthetase possesses an angiogenesis-regulating capacity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SYSC_DANRE
515
0
58718
Swiss-Prot
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
T429A
the abnormal branching of intersegmental vessels in ko095 mutant is suppressed by the introduction of either wild-type or mutant T429A seryl-tRNA synthetase, T429A lacks the enzymatic activity that catalyzes aminoacylation of transfer RNA for serine
DELTA_C
-
mutant, enzymatically inactive
ko095
-
mutant lacking aminoacylation activity
T429A
-
mutant, enzymatically inactive
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
by glutathione Sepharose beads
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
into the vector pGEX6p3 for expression in Escherichia coli cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fukui, H.; Hanaoka, R.; Kawahara, A.
Noncanonical activity of seryl-tRNA synthetase is involved in vascular development
Circ. Res.
104
1253-1259
2009
Danio rerio (Q6DRC0), Danio rerio
Manually annotated by BRENDA team
Herzog, W.; Mueller, K.; Huisken, J.; Stainier, D.Y.
Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development
Circ. Res.
104
1260-1266
2009
Danio rerio, Homo sapiens
Manually annotated by BRENDA team
Kawahara, A.; Stainier, D.Y.
Noncanonical activity of seryl-transfer RNA synthetase and vascular development
Trends Cardiovasc. Med.
19
179-182
2009
Danio rerio, Homo sapiens
Manually annotated by BRENDA team