Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.11 extracted from

  • Kawahara, A.; Stainier, D.Y.
    Noncanonical activity of seryl-transfer RNA synthetase and vascular development (2009), Trends Cardiovasc. Med., 19, 179-182.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
DELTA_C mutant, enzymatically inactive Danio rerio
ko095 mutant lacking aminoacylation activity Danio rerio
T429A mutant, enzymatically inactive Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-serine + tRNASer Homo sapiens
-
AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASer Danio rerio
-
AMP + diphosphate + L-seryl-tRNASer
-
?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-serine + tRNASer
-
Homo sapiens AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASer
-
Danio rerio AMP + diphosphate + L-seryl-tRNASer
-
?

Synonyms

Synonyms Comment Organism
Seryl-transfer RNA synthetase
-
Homo sapiens
Seryl-transfer RNA synthetase
-
Danio rerio

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Danio rerio

General Information

General Information Comment Organism
malfunction impairment of zygotic Sars function leads to a significant dilatation of the aortic arch vessels and aberrant branching of cranial and intersegmental vessels Danio rerio