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Adenomatous Polyposis Coli
Proteins of the Wnt signaling pathway as targets for the regulation of CD133+ cancer stem cells in glioblastoma.
Amyotrophic Lateral Sclerosis
Common mutations of AAA ATPase p97 and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
Arthritis, Experimental
Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist.
Bacterial Infections
Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Breast Neoplasms
Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer.
Breast Neoplasms
Proteasome functioning in breast cancer: connection with clinical-pathological factors.
Carcinogenesis
A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.
Carcinogenesis
A possible connection between adhesion regulating molecule 1 overexpression and nuclear factor kappa B activity in hepatocarcinogenesis.
Carcinogenesis
Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.
Carcinoma
Changes in the Proteasome Pool during Malignant Transformation of Mouse Liver Cells.
Carcinoma
PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR/p70S6K pathway.
Carcinoma, Ovarian Epithelial
[Expression and activity of proteases in metastasis of ovarian cancer].
Cardiomegaly
Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3? phosphorylation.
Cataract
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress.
Colonic Neoplasms
Differential proteomics mass spectrometry of melanosis coli.
Colorectal Neoplasms
PSMC5 Promotes Proliferation and Metastasis of Colorectal Cancer by Activating Epithelial-Mesenchymal Transition Signaling and Modulating Immune Infiltrating Cells.
Cystic Fibrosis
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome.
Cysts
A reduced VWA domain-containing proteasomal ubiquitin receptor of Giardia lamblia localizes to the flagellar pore regions in microtubule-dependent manner.
Deafness
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress.
Dehydration
AREB1 Is a transcription activator of novel ABRE-dependent ABA signaling that enhances drought stress tolerance in Arabidopsis.
Dentin Dysplasia
Vacuolar protein sorting 4B regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells through the Wnt-?-catenin signalling pathway.
Dystonic Disorders
Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism.
Dystonic Disorders
Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster.
Frontotemporal Dementia
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.
Glioblastoma
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival.
Heart Failure
Impaired Assembly and Post-Translational Regulation of 26S Proteasome in Human End Stage Heart Failure.
Hypersensitivity
Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide.
Hypersensitivity
The RPT2 subunit of the 26S proteasome directs complex assembly, histone dynamics, and gametophyte and sporophyte development in Arabidopsis.
Hypertension
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Infections
Efficient Inhibition of Streptococcus agalactiae by AIEgen-Based Fluorescent Nanomaterials.
Infections
Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Infections
Proteomic analysis of papaya (Carica papaya L.) displaying typical sticky disease symptoms.
Infections
Simultaneous neutralization and innate immune detection of a replicating virus by TRIM21.
Infections
The 19S proteasome activator promotes human cytomegalovirus immediate early gene expression through proteolytic and nonproteolytic mechanisms.
Infections
Tomato 26S Proteasome subunit RPT4a regulates ToLCNDV transcription and activates hypersensitive response in tomato.
Leukemia
The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97.
Lung Neoplasms
Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells.
Lymphoma, B-Cell
Differential expression of serum proteins in multiple myeloma.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Machado-Joseph Disease
Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
Malaria
Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders.
Malaria, Cerebral
Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders.
Multiple Myeloma
Gabapentin Inhibits Bortezomib-Induced Mechanical Allodynia Through Supraspinal Action in Mice.
Muscular Atrophy
NF-?B activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.
Muscular Diseases
Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis.
Muscular Diseases
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.
Myocardial Ischemia
Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations.
Neoplasm Metastasis
PSMC5 Promotes Proliferation and Metastasis of Colorectal Cancer by Activating Epithelial-Mesenchymal Transition Signaling and Modulating Immune Infiltrating Cells.
Neoplasms
A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells.
Neoplasms
A minimal set of internal control genes for gene expression studies in head and neck squamous cell carcinoma.
Neoplasms
A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.
Neoplasms
A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.
Neoplasms
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation.
Neoplasms
Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.
Neoplasms
Changes in the Proteasome Pool during Malignant Transformation of Mouse Liver Cells.
Neoplasms
Circulating protein and antibody biomarker for personalized cancer immunotherapy.
Neoplasms
Common mutations of AAA ATPase p97 and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
Neoplasms
Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1.
Neoplasms
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.
Neoplasms
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Neoplasms
Identification of the antigens predominantly reacted with serum from patients with hepatocellular carcinoma.
Neoplasms
Immunohistochemical study of the ubiquitin-nuclear factor-kB pathway in the endometrium of the baboon (Papio anubis) with and without endometriosis.
Neoplasms
Overview of proteasome inhibitor-based anti-cancer therapies: perspective on bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome system.
Neoplasms
Proteasome functioning in breast cancer: connection with clinical-pathological factors.
Neoplasms
PSMC5 Promotes Proliferation and Metastasis of Colorectal Cancer by Activating Epithelial-Mesenchymal Transition Signaling and Modulating Immune Infiltrating Cells.
Neoplasms
Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells.
Neoplasms
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Neoplasms
Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties.
Neoplasms
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.
Neoplasms
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
Neoplasms
Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.
Neoplasms
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.
Neoplasms
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Neoplasms
The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death.
Neoplasms
The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53.
Neoplasms
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53.
Neoplasms
The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of Multiple Myeloma.
Neoplasms
The potential role of ubiquitin c-terminal hydrolases in oncogenesis.
Neoplasms
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Neoplasms
Ubiquitin-Independent Proteasomal Degradation of Tumor Suppressors by Human Cytomegalovirus pp71 Requires the 19S Regulatory Particle.
Neoplasms
[Expression and activity of proteases in metastasis of ovarian cancer].
Neurodegenerative Diseases
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.
Neurodegenerative Diseases
Common mutations of AAA ATPase p97 and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
Neurodegenerative Diseases
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.
Neuroinflammatory Diseases
Inhibition of 26S protease regulatory subunit 7 (MSS1) suppresses neuroinflammation.
Osteitis Deformans
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.
Ovarian Neoplasms
RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells.
Ovarian Neoplasms
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Pancreatic Neoplasms
Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome.
Parasitic Diseases
The bacterial-like HslVU protease complex subunits are involved in the control of different cell cycle events in trypanosomatids.
Phenylketonurias
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Pre-Eclampsia
[Microarray analysis of differentially expressed genes in peripheral leucocytes derived from severe preeclampsia and normotensive pregnancies]
Prostatic Neoplasms
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Pulmonary Disease, Chronic Obstructive
NF-?B activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.
Purpura, Thrombocytopenic, Idiopathic
Ubiquitin/proteasome-rich particulate cytoplasmic structures (PaCSs) in the platelets and megakaryocytes of ANKRD26-related thrombo-cytopenia.
Rectal Neoplasms
Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.
Sarcoma
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation.
Sarcoma, Ewing
Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.
Spastic Paraplegia, Hereditary
Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.
Spastic Paraplegia, Hereditary
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.
Spastic Paraplegia, Hereditary
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III.
Spastic Paraplegia, Hereditary
The AAA ATPase spastin links microtubule severing to membrane modelling.
Starvation
Proteasome 19S RP and translation preinitiation complexes are secreted within exosomes upon serum starvation.
Tauopathies
Interaction between ?-synuclein and tau in Parkinson's disease Comment on Wills et al.: Elevated tauopathy and ?-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218.
Tuberculosis
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue.
Tuberculosis
Characterization of ATPase activity of the AAA ARC from Bifidobacterium longum subsp. infantis.
Tuberculosis
Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue gene produces a slow-growing strain that persists in host tissues.
Tuberculosis
Induced Folding Under Membrane Mimetic and Acidic Conditions Implies Undiscovered Biological Roles of Prokaryotic Ubiquitin-Like Protein Pup.
Tuberculosis
Mycobacterium tuberculosis proteasomal ATPase Mpa has a ?-grasp domain that hinders docking with the proteasome core protease.
Tuberculosis
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa.
Virus Diseases
A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.
Virus Diseases
Tomato 26S Proteasome subunit RPT4a regulates ToLCNDV transcription and activates hypersensitive response in tomato.
Werner Syndrome
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.
Zellweger Syndrome
A common PEX1 frameshift mutation in patients with disorders of peroxisome biogenesis correlates with the severe Zellweger syndrome phenotype.
Zellweger Syndrome
Novel PEX1 coding mutations and 5' UTR regulatory polymorphisms.
Zellweger Syndrome
PEX1 mutations in the Zellweger spectrum of the peroxisome biogenesis disorders.
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5.6.1.5 proteasome ATPase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
