EC Number   |
Natural Substrates |
|---|
   5.6.1.5 | ATP + H2O |
- |
| 5.6.1.5 | ATP + H2O + polypeptide |
- |
| 5.6.1.5 | ATP + H2O + polypeptide |
ATP hydrolysis is required for degradation of polyubiquitinated proteins by the 26S proteasome. ATP hydrolysis triggers rapid dissociation of the 19S regulatory particles from immunopurified 26S complexes in a manner coincident with release of the bulk of proteasome-interacting proteins. A controlled dissociation of the 19S regulatory particles from the 26S proteasome is part of the mechanism of protein degradation |
| 5.6.1.5 | CTP + H2O + polypeptide |
- |
| 5.6.1.5 | more |
PA700 prevents fibril formation of both wild-type and A53T alpha-synuclein. It is hypothesized that PA700 sequesters alpha-synuclein oligomeric species that are the precursors of the fibrillar form of the protein, thus preventing its assembly into fibrils |
| 5.6.1.5 | more |
RPT5a and RPT5b are essential for male gametophyte development, display accession-dependent redundancy and are crucial in cell cycle progression |
| 5.6.1.5 | more |
TBP-1 functions as a coactivator of AR with TBP-1-interacting protein, TBP-1 interacts with TBP-1-interacting protein in vitro via its N-terminal leucine zipper structure |
| 5.6.1.5 | more |
a specific interaction between Rpt1 and Hsm3 is required for the proper assembly of the 19 S RP |
| 5.6.1.5 | more |
UNI/uni-1D interacts with the regulatory particle triple-ATPase (RPT) subunits 2a and 2b, base components of the 19S regulatory particle in the 26S proteasome |
