Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 5.5.1.19 - lycopene beta-cyclase and Organism(s) Synechococcus elongatus and UniProt Accession Q55276

for references in articles please use BRENDA:EC5.5.1.19
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Synechococcus elongatus
UNIPROT: Q55276
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Synechococcus elongatus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
lycopene cyclase, lycopene beta-cyclase, cyc-b, lcy-b, dclcyb1, lycopene beta cyclase, lcyb1, crtl-b, beta-lcy, lcyb2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CrtL
-
-
-
-
CrtL-b
-
-
-
-
CrtY
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
carotenoid beta-end group lyase (decyclizing)
The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
lycopene
beta-carotene
show the reaction diagram
neurosporene
beta-zeacarotene
show the reaction diagram
-
-
-
?
additional information
?
-
the enzyme does not cyclize xi-carotene
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
lycopene
beta-carotene
show the reaction diagram
the crtL gene product converts the acyclic hydrocarbon lycopene into the bicyclic beat-carotene, an essential component of the photosynthetic apparatus in oxygen-evolving organisms and a source of vitamin A in human and animal nutrition
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(4-methylphenoxy)triethylamine hydrochloride
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6
calculated from sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
46125
x * 46125, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 46125, calculated from sequence
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
mutation that confers resistance to 2-(4-methylphenoxy)triethylamine hydrochloride in Synechococcus sp PCC7942 is identified as a point mutation in the promoter region of crtL
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cunningham, F.X. Jr.; Sun, Z.; Chamovitz, D.; Hirschberg, J.; Gantt, E.
Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942
Plant Cell
6
1107-1121
1994
Synechococcus elongatus (Q55276), Synechococcus elongatus PCC 7942 (Q55276)
Manually annotated by BRENDA team