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Information on EC 5.4.99.43 - 21S rRNA pseudouridine2819 synthase and Organism(s) Saccharomyces cerevisiae and UniProt Accession Q06244

for references in articles please use BRENDA:EC5.4.99.43
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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.43 21S rRNA pseudouridine2819 synthase
IUBMB Comments
The enzyme specifically acts on uridine2819 in 21S rRNA.
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This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: Q06244
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
21S rRNA uridine2819
=
21S rRNA pseudouridine2819
Synonyms
pus5p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
21S rRNA-uridine2819 uracil mutase
The enzyme specifically acts on uridine2819 in 21S rRNA.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
21S rRNA uridine2819
21S rRNA pseudouridine2819
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
21S rRNA uridine2819
21S rRNA pseudouridine2819
show the reaction diagram
pseudouridine2819 in mitochondrial 21S rRNA is not essential for cell viability
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D71A
inactive mutant enzyme
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
the selective uridine-pseudouridine conversion at position 2819 in mitochondrial 21S rRNA is restored when the deleted yeast strain is transformed by a plasmid expressing the wild-type YLR165c ORF
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ansmant, I.; Massenet, S.; Grosjean, H.; Motorin, Y.; Branlant, C.
Identification of the Saccharomyces cerevisiae RNA:pseudouridine synthase responsible for formation of psi2819 in 21S mitochondrial ribosomal RNA
Nucleic Acids Res.
28
1941-1946
2000
Saccharomyces cerevisiae (Q06244), Saccharomyces cerevisiae
Manually annotated by BRENDA team