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Information on EC 5.3.3.22 - lutein isomerase and Organism(s) Homo sapiens and UniProt Accession Q16518

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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.22 lutein isomerase
IUBMB Comments
The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.
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This record set is specific for:
Homo sapiens
UNIPROT: Q16518
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
meso-zeaxanthin isomerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
meso-zeaxanthin isomerase
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-
-
-
Rpe65
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
lutein DELTA4-DELTA5-isomerase
The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
lutein
meso-zeaxanthin
show the reaction diagram
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-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron
nonheme iron center
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzyme catalyzes both the isomerization of all-trans-retinyl esters to 11-cis-retinol in the vertebrate visual cycle, cf. EC. 3.1.1.64, and is responsible for the production of meso-zeaxanthin, i.e. (3R,3'S)-beta,beta-carotene-3,3'-diol in vertebrates
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
overexpression of RPE65 in cell culture leads to the production of meso-zeaxanthin from lutein
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RPE65_HUMAN
533
0
60948
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shyam, R.; Gorusupudi, A.; Nelson, K.; Horvath, M.P.; Bernstein, P.S.
RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye
Proc. Natl. Acad. Sci. USA
114
10882-10887
2017
Gallus gallus (Q9YGX2), Gallus gallus, Homo sapiens (Q16518), Homo sapiens
Manually annotated by BRENDA team