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Literature summary for 5.3.3.22 extracted from

  • Shyam, R.; Gorusupudi, A.; Nelson, K.; Horvath, M.P.; Bernstein, P.S.
    RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye (2017), Proc. Natl. Acad. Sci. USA, 114, 10882-10887 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.3.22

Crystallization (Commentary)

Crystallization (Comment) Organism
structural docking shows that the epsilon ring of lutein fits into the active site of RPE65 close to the nonheme iron center Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron nonheme iron center Homo sapiens
Iron nonheme iron center Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus Q9YGX2 enzyme catalyzes both the isomerization of all-trans-retinyl esters to 11-cis-retinol in the vertebrate visual cycle, cf. EC. 3.1.1.64, and is responsible for the production of meso-zeaxanthin, i.e. (3R,3'S)-beta,beta-carotene-3,3'-diol in vertebrates
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Homo sapiens Q16518 enzyme catalyzes both the isomerization of all-trans-retinyl esters to 11-cis-retinol in the vertebrate visual cycle, cf. EC. 3.1.1.64, and is responsible for the production of meso-zeaxanthin, i.e. (3R,3'S)-beta,beta-carotene-3,3'-diol in vertebrates
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Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Homo sapiens
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eye
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 Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lutein
-
 Homo sapiens meso-zeaxanthin
-
 ?
lutein
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 Gallus gallus meso-zeaxanthin
-
 ?

Synonyms

Synonyms Comment Organism
Rpe65
-
 Homo sapiens
Rpe65
-
 Gallus gallus

Expression

Organism Comment Expression
Gallus gallus RNA is upregulated 23fold at the time of meso-zeaxanthin production during chicken eye development up

General Information

General Information Comment Organism
physiological function overexpression of RPE65 in cell culture leads to the production of meso-zeaxanthin from lutein Homo sapiens
physiological function overexpression of RPE65 in cell culture leads to the production of meso-zeaxanthin from lutein. Pharmacologic inhibition of RPE65 function results in significant inhibition of meso-zeaxanthin biosynthesis during chicken eye development Gallus gallus