Information on EC 5.1.3.24 - N-acetylneuraminate epimerase

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EC Tree
     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.24 N-acetylneuraminate epimerase
IUBMB Comments
Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
N-acetylneuraminate mutarotase, sialic acid epimerase, YjhT, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
aceneuramate = N-acetyl-beta-neuraminate
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(1b)
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N-acetyl-alpha-neuraminate = aceneuramate
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(1a)
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N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate
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overall reaction
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