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Disease on EC 4.3.2.7 - glutathione-specific gamma-glutamylcyclotransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Atherosclerosis
Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.
Breast Neoplasms
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2?-ATF4 pathway.
Development of a novel prognostic score for breast cancer patients using mRNA expression of CHAC1.
Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.
Carcinogenesis
Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.
Upregulation of LYAR induces neuroblastoma cell proliferation and survival.
Carcinoma
Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.
Cardiovascular Diseases
Source of Dietary Fat in Pig Diet Affects Adipose Expression of Genes Related to Cancer, Cardiovascular, and Neurodegenerative Diseases.
Colorectal Neoplasms
CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.
Cystic Fibrosis
CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa.
Glioma
The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity.
Heart Failure
Heart failure and the glutathione cycle: an integrated view.
Infections
CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa.
CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi.
Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells.
Neoplasm Metastasis
Higher expression of cation transport regulator-like protein 1 (CHAC1) predicts of poor outcomes in uveal melanoma (UM) patients.
Neoplasms
CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.
Development of a novel prognostic score for breast cancer patients using mRNA expression of CHAC1.
Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients.
Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.
Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells.
Higher expression of cation transport regulator-like protein 1 (CHAC1) predicts of poor outcomes in uveal melanoma (UM) patients.
Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.
Source of Dietary Fat in Pig Diet Affects Adipose Expression of Genes Related to Cancer, Cardiovascular, and Neurodegenerative Diseases.
Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.
The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity.
Transcriptomic Profiling of MDA-MB-231 Cells Exposed to
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level.
Neuroblastoma
Upregulation of LYAR induces neuroblastoma cell proliferation and survival.
Ovarian Neoplasms
Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients.
Periodontitis
Detection of Serum miRNAs Affecting Liver Apoptosis in a Periodontitis Rat Model.
Prostatic Neoplasms
ChaC glutathione specific ?-glutamylcyclotransferase 1 inhibits cell viability and increases the sensitivity of prostate cancer cells to docetaxel by inducing endoplasmic reticulum stress and ferroptosis.
Squamous Cell Carcinoma of Head and Neck
Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.
RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with radiotherapy response of nasopharyngeal carcinoma and prognosis of head and neck cancer.
Starvation
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2?-ATF4 pathway.
Stomach Neoplasms
Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells.
Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis.
Teratoma
CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells.
Triple Negative Breast Neoplasms
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2?-ATF4 pathway.