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Information on EC 4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase
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EC Tree
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyaseIUBMB Comments
'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2.
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Word Map
- 4.2.99.18
- strand
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exonuclease
- glycosylases
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single-stranded
- pyrimidine
- endonucleases
- 8-oxoguanine
- nick
- thymine
- uracil
- duplex
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genotoxic
- xrcc1
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phosphodiester
- comet
- deoxyribose
- methanesulfonate
- mispairs
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uracil-dna
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depurinated
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beta-elimination
-
excise
- formamidopyrimidine
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3'-phosphatase
- 7,8-dihydro-8-oxoguanine
- tetrahydrofuran
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site-containing
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mutyh
-
endonucleolytic
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xeroderma
- pigmentosum
-
base-excision
- 3'-phosphodiesterase
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cross-complementing
- 8-oxo-7,8-dihydroguanine
- fen1
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unrepaired
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formamidopyrimidine-dna
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incises
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long-patch
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dna-repair
-
uracil-containing
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ser326cys
- dihydrouracil
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arg399gln
- 3'-exonuclease
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reduction-oxidation
-
enzyme-dna
- medicine
-
gap-filling
-
damage-specific
- analysis
- diagnostics
- biotechnology
- drug development
- pharmacology
The enzyme appears in viruses and cellular organisms
Reaction Schemes
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Synonyms
ap endonuclease, ref-1, ape1/ref-1, apex1, ape/ref-1, apurinic/apyrimidinic endonuclease 1, ap lyase, ape-1, alkbh1, endo iii, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AP 1
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AP Dnase
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AP endo
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AP endonuclease
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AP endonuclease Class I
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AP lyase
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AP-endonuclease
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Ape
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APEN
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APEX nuclease
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APN1
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apurinic DNA endonuclease
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apurinic endodeoxyribonuclease
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apurinic endonuclease
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apurinic-apyrimidinic DNA endonuclease
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apurinic-apyrimidinic endodeoxyribonuclease
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apurinic-apyrimidinic endonuclease
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apurinic/apyrimidinic lyase
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apurinic/apyrimidinic specific endonuclease
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apyrimidinic endonuclease
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class II apurinic/apyrimidinic(AP)-endonuclease
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deoxyribonuclease (apurinic or apyrimidinic)
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E. coli endonuclease III
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endodeoxyribonuclease
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endodeoxyribonuclease III
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endonuclease III
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endonuclease VI
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Escherichia coli endonuclease III
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HAP1
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HAP1h
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Micrococcus luteus UV endonuclease
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MMH
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Nfo
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Ntg1p
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Ntg2p
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NTH1
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nuclease, apurinic endodeoxyribo-
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nuclease, apurinic-apyrimidinic endodeoxyribo-
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nuclease, endodeoxyribo-, III
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phage-T4 UV endonuclease
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REF-1 protein
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Ref1
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UV endo V
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UV endonuclease
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UV endonuclease V
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SYSTEMATIC NAME
IUBMB Comments
DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase
'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2.
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CAS REGISTRY NUMBER
COMMENTARY
60184-90-9
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61811-29-8
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats.
Acute-On-Chronic Liver Failure
SHYCD induces APE1/Ref-1 subcellular localization to regulate the p53-apoptosis signaling pathway in the prevention and treatment of acute on chronic liver failure.
Adenocarcinoma
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Adenocarcinoma
APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma: Characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.
Adenocarcinoma
APEX1 Asp148Glu Gene Polymorphism is a Risk Factor for Lung Cancer in Relation to Smoking in Japanese.
Adenocarcinoma
Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2.
Adenocarcinoma
Effect of Isothiocyanates on Nuclear Accumulation of NF-kappaB, Nrf2, and Thioredoxin in Caco-2 Cells.
Adenocarcinoma
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Adenocarcinoma
Genetic characteristics and prognostic implications of m1A regulators in pancreatic cancer.
Adenocarcinoma
Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas.
Adenocarcinoma
Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.
Adenocarcinoma
Targeted Proteomics for Multiplexed Verification of Markers of Colorectal Tumorigenesis.
Adenocarcinoma
The expression profile and prognostic value of APE/Ref-1 and NPM1 in high-grade serous ovarian adenocarcinoma.
Adenocarcinoma of Lung
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Adenocarcinoma of Lung
Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.
Adenocarcinoma of Lung
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells.
Adenoma
APE/Ref-1 is increased in nuclear fractions of human thyroid hyperfunctioning nodules.
Adenoma
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Adenoma
Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.
Adenoma
Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.
Adenoma
Targeted Proteomics for Multiplexed Verification of Markers of Colorectal Tumorigenesis.
Adenoma
[Effects of beech dust extract on lipid peroxidation and expression of ref-1 gene of mouse lung tissue]
Adenoma, Pleomorphic
Apurinic/apyrimidinic endonuclease 1 (APE1) is overexpressed in malignant transformation of salivary gland pleomorphic adenoma.
Adenomatous Polyposis Coli
Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps.
Adenoviridae Infections
[Adenoviral-mediated APE/Ref-1 expression protects rat spiral ganglion cells from oxidative damage]
African Swine Fever
A unique DNA-binding mode of African swine fever virus AP endonuclease.
African Swine Fever
African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA.
African Swine Fever
African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages.
African Swine Fever
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA.
Alzheimer Disease
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients.
Alzheimer Disease
Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus.
Alzheimer Disease
[Expression of Ref-1 in hippocampus CA1 area of rats with Alzheimer's disease]
Ameloblastoma
Immunoexpression of DNA base excision repair and nucleotide excision repair proteins in ameloblastomas, syndromic and non-syndromic odontogenic keratocysts and dentigerous cysts.
Amyotrophic Lateral Sclerosis
Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Molecular genetic analysis of the APEX nuclease gene in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Mutant AP endonuclease in patients with amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Screening of AP endonuclease as a candidate gene for amyotrophic lateral sclerosis (ALS).
Astrocytoma
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
Ataxia Telangiectasia
Apurinic and/or apyrimidinic endonuclease activity in ataxia telangiectasia cell extracts.
Ataxia Telangiectasia
Apurinic DNA endonuclease activities in repair-deficient human cell lines.
Ataxia Telangiectasia
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Atherosclerosis
APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.
Atherosclerosis
Plasma APE1/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE-/- Mice.
Atherosclerosis
Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis.
Biliary Tract Neoplasms
Clinical implications of APEX1 and Jagged1 as chemoresistance factors in biliary tract cancer.
Biliary Tract Neoplasms
Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
Brain Diseases
The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.
Brain Edema
Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage.
Brain Injuries, Traumatic
Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury.
Brain Ischemia
Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia.
Brain Ischemia
Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus.
Brain Ischemia
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Brain Ischemia
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice.
Brain Neoplasms
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Breast Neoplasms
A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase.
Breast Neoplasms
Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression.
Breast Neoplasms
Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis.
Breast Neoplasms
Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China.
Breast Neoplasms
Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer.
Breast Neoplasms
Extreme Expression of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry.
Breast Neoplasms
Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Breast Neoplasms
Germline variations of apurinic/apyrimidinic endonuclease 1 (APEX1) detected in female breast cancer patients.
Breast Neoplasms
Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis.
Breast Neoplasms
Impact of genetic polymorphisms in base excision repair genes on the risk of breast cancer in a Korean population.
Breast Neoplasms
Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.
Breast Neoplasms
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Breast Neoplasms
Polymorphisms in three base excision repair genes and breast cancer risk in Thai women.
Breast Neoplasms
Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas.
Breast Neoplasms
Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer.
Breast Neoplasms
Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population.
Breast Neoplasms
Topoisomerase IIalpha and APE/ref-1 are associated with pathologic response to primary anthracycline-based chemotherapy for breast cancer.
Carcinogenesis
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Carcinogenesis
APE1/Ref-1 enhances DNA binding activity of mutant p53 in a redox-dependent manner.
Carcinogenesis
APEX nuclease (multifunctional DNA repair enzyme) 1 gene Asp148Glu polymorphism and cancer risk: a meta-analysis involving 58 articles and 48903 participants.
Carcinogenesis
Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.
Carcinogenesis
Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China.
Carcinogenesis
Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils.
Carcinogenesis
Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells.
Carcinogenesis
Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
Carcinogenesis
Dysregulated Expression and Subcellular Localization of Base Excision Repair (BER) Pathway Enzymes in Gallbladder Cancer.
Carcinogenesis
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.
Carcinogenesis
Helicobacter pylori genotype and polymorphisms in DNA repair enzymes: Where do they correlate in gastric cancer?
Carcinogenesis
Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis risk.
Carcinogenesis
Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.
Carcinogenesis
MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1.
Carcinoma
APEX1 Asp148Glu Gene Polymorphism is a Risk Factor for Lung Cancer in Relation to Smoking in Japanese.
Carcinoma
APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas.
Carcinoma
Apurinic/apyrimidinic endonuclease 1 (APE1) is overexpressed in malignant transformation of salivary gland pleomorphic adenoma.
Carcinoma
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma.
Carcinoma
Apurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-?B-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue.
Carcinoma
Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.
Carcinoma
Association between polymorphisms in genes related to DNA base-excision repair with risk and prognosis of oropharyngeal squamous cell carcinoma.
Carcinoma
Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.
Carcinoma
DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in oral tongue squamous cell carcinoma.
Carcinoma
Expression Pattern of Apurinic/Apyrimidinic Endonuclease in Sinonasal Squamous Cell Carcinoma.
Carcinoma
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Carcinoma
hOGG1 gene alterations in human clear cell carcinomas of the kidney: effect of single mutations in hOGG1 gene on substrate specificity of the hOGG1 protein.
Carcinoma
Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1.
Carcinoma
N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals.
Carcinoma
Nuclear localization of human AP endonuclease 1 (HAP1/Ref-1) associates with prognosis in early operable non-small cell lung cancer (NSCLC).
Carcinoma
Predictive value of genetic variants XRCC1 rs1799782, APEX1 rs1760944, and MUTYH rs3219489 for adjuvant concurrent chemoradiotherapy outcomes in oral squamous cell carcinoma patients.
Carcinoma
Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas.
Carcinoma
Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma.
Carcinoma
The impact of apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) on treatment response and survival in oral squamous cell carcinoma.
Carcinoma
The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.
Carcinoma
Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis.
Carcinoma, Hepatocellular
AlkB Homologue 1 Demethylates N3-Methylcytidine in mRNA of Mammals.
Carcinoma, Hepatocellular
APE1/Ref-1 enhances DNA binding activity of mutant p53 in a redox-dependent manner.
Carcinoma, Hepatocellular
APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas.
Carcinoma, Hepatocellular
APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Differential expression of APE1 in hepatocellular carcinoma and the effects on proliferation and apoptosis of cancer cells.
Carcinoma, Hepatocellular
Genetic variants of APEX1 p.Asp148Glu and XRCC1 p.Gln399Arg with the susceptibility of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters.
Carcinoma, Hepatocellular
Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells.
Carcinoma, Hepatocellular
Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Retraction: Role and potential targeting of hepatic apurinic/apyrimidinic endonuclease-1 and cyclin-dependent kinase-4 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Role and potential targeting of hepatic apurinic/apyrimidinic endonuclease-1 and cyclin-dependent kinase-4 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.
Carcinoma, Hepatocellular
The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression.
Carcinoma, Non-Small-Cell Lung
A randomized, double-blind, placebo-controlled study of B-cell lymphoma 2 homology 3 mimetic gossypol combined with docetaxel and cisplatin for advanced non-small cell lung cancer with high expression of apurinic/apyrimidinic endonuclease 1.
Carcinoma, Non-Small-Cell Lung
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Carcinoma, Non-Small-Cell Lung
Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1.
Carcinoma, Non-Small-Cell Lung
Clinical value of serum Ape1/Ref-1 combined with TGF-?1 monitoring in predicting the occurrence of radiation pneumonitis (RP) in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
Carcinoma, Non-Small-Cell Lung
Impact of the APE1 Redox Function Inhibitor E3330 in Non-small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion.
Carcinoma, Non-Small-Cell Lung
Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1.
Carcinoma, Non-Small-Cell Lung
Nuclear localization of human AP endonuclease 1 (HAP1/Ref-1) associates with prognosis in early operable non-small cell lung cancer (NSCLC).
Carcinoma, Non-Small-Cell Lung
Prognostic biological factors of radiation pneumonitis after stereotactic body radiation therapy combined with pulmonary perfusion imaging.
Carcinoma, Non-Small-Cell Lung
Serum APE1 as a predictive marker for platinum-based chemotherapy of non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Serum APE1 Autoantibodies: A Novel Potential Tumor Marker and Predictor of Chemotherapeutic Efficacy in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Soy Isoflavones Augment Radiation Effect by Inhibiting APE1/Ref-1 DNA Repair Activity in Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
[Correlations between Ape1/Ref-1, ICAM-1 and IL-17A Levels in Serum and Radiation Pneumonitis for Local Advanced Non-small Cell Lung Cancer Patients].
Carcinoma, Ovarian Epithelial
Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene.
Carcinoma, Ovarian Epithelial
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
Carcinoma, Pancreatic Ductal
Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2.
Carcinoma, Renal Cell
APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas.
Carcinoma, Squamous Cell
APEX1 Asp148Glu Gene Polymorphism is a Risk Factor for Lung Cancer in Relation to Smoking in Japanese.
Carcinoma, Squamous Cell
Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in oral tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Expression Pattern of Apurinic/Apyrimidinic Endonuclease in Sinonasal Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Cardiotoxicity
Antifungal Miconazole Induces Cardiotoxicity via Inhibition of APE/Ref-1-Related Pathway in Rat Neonatal Cardiomyocytes.
Cardiovascular Diseases
SY 17-1 DYNAMIC REGULATION OF REDOX REGULATING FACTOR APE1/REF-1 ON THE OXIDATIVE STRESS AND VASCULAR INFLAMMATION.
Carotid Artery Thrombosis
Ref-1 protects against FeCl3-induced thrombosis and tissue factor expression via the GSK3?-NF-?B pathway.
Cataract
The Changes of 8-OHdG, hOGG1, APE1 and Pol ? in Lenses of Patients with Age-Related Cataract.
Central Nervous System Diseases
[Research progress of Ape/Ref-1 and central nervous system diseases]
Cerebral Infarction
Haplotype-based case-control study between human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and cerebral infarction.
Cerebral Infarction
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice.
Cerebral Infarction
[The protective mechanism of fructose-1, 6-diphosphate on ischemic brain injury]
Cholangiocarcinoma
APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas.
Cholangiocarcinoma
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Cholera
Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration.
Choroidal Neovascularization
Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.
Choroidal Neovascularization
Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.
Choroidal Neovascularization
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.
Cockayne Syndrome
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates.
Colitis
Apurinic/apyrimidinic endonuclease 1, the sensitive marker for DNA deterioration in dextran sulfate sodium-induced acute colitis.
Colitis
Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.
Colitis, Ulcerative
Functional polymorphisms in XRCC-1 and APE-1 contribute to increased apoptosis and risk of ulcerative colitis.
Colonic Neoplasms
Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
Colonic Neoplasms
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
Colonic Neoplasms
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged.
Colorectal Neoplasms
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
Colorectal Neoplasms
Evaluation and Clinical Significance of Jagged-1-activated Notch Signaling by APEX1 in Colorectal Cancer.
Colorectal Neoplasms
Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.
Colorectal Neoplasms
Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome.
Colorectal Neoplasms, Hereditary Nonpolyposis
Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome.
Colorectal Neoplasms, Hereditary Nonpolyposis
Temozolomide: Mechanisms of Action, Repair and Resistance.
Corneal Dystrophies, Hereditary
Polymorphism of the APEX nuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Coronary Artery Disease
Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease.
Dementia, Vascular
[Effects of Ruanmailing Oral Liquid on spatial learning and memory ability and expression of APE/Ref-1 in hippocampal CA1 region in rats with experimental vascular dementia.]
Dentigerous Cyst
Immunoexpression of DNA base excision repair and nucleotide excision repair proteins in ameloblastomas, syndromic and non-syndromic odontogenic keratocysts and dentigerous cysts.
Diabetes Mellitus
Functional polymorphism of hOGG1 gene is associated with type 2 diabetes mellitus in Chinese population.
Diabetes Mellitus, Type 2
Functional polymorphism of hOGG1 gene is associated with type 2 diabetes mellitus in Chinese population.
dna-(apurinic or apyrimidinic site) lyase deficiency
ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.
dna-(apurinic or apyrimidinic site) lyase deficiency
AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation.
dna-(apurinic or apyrimidinic site) lyase deficiency
AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans.
Encephalocele
Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.
End Stage Liver Disease
SHYCD induces APE1/Ref-1 subcellular localization to regulate the p53-apoptosis signaling pathway in the prevention and treatment of acute on chronic liver failure.
Endodermal Sinus Tumor
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Endotoxemia
Identification of plasma APE1/Ref-1 in lipopolysaccharide-induced endotoxemic rats: implication of serological biomarker for an endotoxemia.
Ependymoma
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.
Esophageal Neoplasms
Apurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-?B-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue.
Esophageal Neoplasms
Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.
Esophageal Squamous Cell Carcinoma
Apurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-?B-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue.
Esophageal Squamous Cell Carcinoma
Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.
Essential Hypertension
Haplotype-based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hypertension.
exodeoxyribonuclease iii deficiency
AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans.
Eye Diseases
Polymorphism of the APEX nuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Fetal Growth Retardation
Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction.
Fuchs' Endothelial Dystrophy
Polymorphism of the APEX nuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Gastritis
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Gastritis
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Gastrointestinal Neoplasms
Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis.
Glioblastoma
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
Glioblastoma
APE1/REF-1 down-regulation enhances the cytotoxic effects of temozolomide in a resistant glioblastoma cell line.
Glioblastoma
CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.
Glioblastoma
Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging.
Glioblastoma
Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme.
Glioblastoma
Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.
Glioma
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
Glioma
Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy.
Glioma
Association and interactions between DNA repair gene polymorphisms and adult glioma.
Glioma
Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.
Glioma
Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines.
Glioma
Radiation resistance in glioma cells determined by DNA damage repair activity of ape1/ref-1.
Glioma
Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines.
Glioma
Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease.
Glioma
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Goiter
APE/Ref-1 is increased in nuclear fractions of human thyroid hyperfunctioning nodules.
Graves Disease
Polymorphisms of DNA base-excision repair genes APE/Ref-1 and XRCC1 are not associated with the risk for Graves' disease.
Head and Neck Neoplasms
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Hearing Loss, Noise-Induced
Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population.
Heart Arrest
Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest.
Hepatitis
APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
Hepatitis
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.
Hepatitis B, Chronic
Differential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis.
Hepatitis, Chronic
Differential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis.
Hypersensitivity
AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase ? knockout mouse embryonic fibroblasts.
Hypersensitivity
Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
Hypersensitivity
Functional variants of human APE1 rescue the DNA repair defects of the yeast AP endonuclease/3'-diesterase-deficient strain.
Hypersensitivity
The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks.
Hypersensitivity
Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast.
Infections
Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.
Infections
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Infections
Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils.
Infections
Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo.
Infections
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Infections
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Infections
Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells.
Infections
N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter pylori Infection.
Infections
[Adenoviral-mediated APE/Ref-1 expression protects rat spiral ganglion cells from oxidative damage]
Intestinal Pseudo-Obstruction
Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.
Keratoconus
Polymorphism of the APEX nuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Kidney Calculi
Apoptosis of human kidney epithelial cells induced by high oxalate and calcium oxalate monohydrate is apurinic/apyrimidinic endonuclease 1 pathway dependent and contributes to kidney stone formation.
Leiomyoma
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Leiomyosarcoma
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Leishmaniasis
Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.
Leukemia
Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies.
Leukemia
Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia.
Leukemia
Endonuclease activation and chromosomal DNA fragmentation during apoptosis in leukemia cells.
Leukemia
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells.
Leukemia
Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.
Leukemia, B-Cell
An integrated approach to identify critical transcription factors in the protection against hydrogen peroxide-induced oxidative stress by Danhong injection.
Leukemia, Myeloid
Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.
Leukemia, Myeloid, Acute
Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies.
Liver Cirrhosis
Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-Fed db/db mice.
Liver Cirrhosis
Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.
Liver Diseases
Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis.
Liver Neoplasms
Correction: Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-?-Induced Activation of Il-8 Production in Liver Cancer Cell Lines.
Liver Neoplasms
Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-?-induced activation of IL-8 production in liver cancer cell lines.
Lung Diseases
GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages.
Lung Diseases
Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages.
Lung Neoplasms
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
Lung Neoplasms
A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy.
Lung Neoplasms
A randomized, double-blind, placebo-controlled study of B-cell lymphoma 2 homology 3 mimetic gossypol combined with docetaxel and cisplatin for advanced non-small cell lung cancer with high expression of apurinic/apyrimidinic endonuclease 1.
Lung Neoplasms
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Lung Neoplasms
APEX1 Asp148Glu Gene Polymorphism is a Risk Factor for Lung Cancer in Relation to Smoking in Japanese.
Lung Neoplasms
Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin?mediated mitophagy.
Lung Neoplasms
Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.
Lung Neoplasms
Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis.
Lung Neoplasms
Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
Lung Neoplasms
Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1.
Lung Neoplasms
Clinical value of serum Ape1/Ref-1 combined with TGF-?1 monitoring in predicting the occurrence of radiation pneumonitis (RP) in non-small cell lung cancer patients.
Lung Neoplasms
Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
Lung Neoplasms
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.
Lung Neoplasms
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
Lung Neoplasms
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.
Lung Neoplasms
Human apurinic/apyrimidinic endonuclease siRNA inhibits the angiogenesis induced by X-ray irradiation in lung cancer cells.
Lung Neoplasms
Impact of the APE1 Redox Function Inhibitor E3330 in Non-small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion.
Lung Neoplasms
Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1.
Lung Neoplasms
miR-296-3p targets APEX1 to suppress cell migration and invasion of non-small-cell lung cancer.
Lung Neoplasms
Nm23-H1 Protein Binds to APE1 at AP Sites and Stimulates AP Endonuclease Activity Following Ionizing Radiation of the Human Lung Cancer A549 Cells.
Lung Neoplasms
Nuclear localization of human AP endonuclease 1 (HAP1/Ref-1) associates with prognosis in early operable non-small cell lung cancer (NSCLC).
Lung Neoplasms
Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells.
Lung Neoplasms
Polymorphisms in DNA repair genes in lung cancer patients living in a coal-mining region.
Lung Neoplasms
Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China.
Lung Neoplasms
Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland.
Lung Neoplasms
Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.
Lung Neoplasms
Prognostic biological factors of radiation pneumonitis after stereotactic body radiation therapy combined with pulmonary perfusion imaging.
Lung Neoplasms
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells.
Lung Neoplasms
Serum APE1 as a predictive marker for platinum-based chemotherapy of non-small cell lung cancer patients.
Lung Neoplasms
Serum APE1 Autoantibodies: A Novel Potential Tumor Marker and Predictor of Chemotherapeutic Efficacy in Non-Small Cell Lung Cancer.
Lung Neoplasms
Soy Isoflavones Augment Radiation Effect by Inhibiting APE1/Ref-1 DNA Repair Activity in Non-small Cell Lung Cancer.
Lung Neoplasms
Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation.
Lung Neoplasms
The contribution of DNA apurinic/apyrimidinic endonuclease genotype and smoking habit to Taiwan lung cancer risk.
Lung Neoplasms
The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese.
Lung Neoplasms
Upregulation of APE/ref-1 in recurrence stage I, non small cell lung cancer.
Lung Neoplasms
XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients.
Lung Neoplasms
[Correlations between Ape1/Ref-1, ICAM-1 and IL-17A Levels in Serum and Radiation Pneumonitis for Local Advanced Non-small Cell Lung Cancer Patients].
Lymphatic Metastasis
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma.
Lymphatic Metastasis
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Lymphatic Metastasis
Prediction of Lymph Node Metastases in Gastric Cancer by Serum APE1 Expression.
Lymphatic Metastasis
The expression profile and prognostic value of APE/Ref-1 and NPM1 in high-grade serous ovarian adenocarcinoma.
Lymphoma
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
Lymphoma
Apurinic/apyrimidinic endonuclease sensitive sites as intermediates in the in vitro degradation of deoxyribonucleic acid by neocarzinostatin.
Lymphoma
Different roles of Fpg and Endo III on catechol-induced DNA damage in extended-term cultures of human lymphocytes and L5178Y mouse lymphoma cells.
Lymphoma
Genotoxicity assessment of propyl thiosulfinate oxide, an organosulfur compound from Allium extract, intended to food active packaging.
Lymphoma, B-Cell
A randomized, double-blind, placebo-controlled study of B-cell lymphoma 2 homology 3 mimetic gossypol combined with docetaxel and cisplatin for advanced non-small cell lung cancer with high expression of apurinic/apyrimidinic endonuclease 1.
Lymphoma, B-Cell
Role and potential targeting of hepatic apurinic/apyrimidinic endonuclease-1 and cyclin-dependent kinase-4 in hepatocellular carcinoma.
Macular Degeneration
Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo.
Medulloblastoma
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Melanoma
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Melanoma
Apurinic/apyrimidinic endonuclease /redox effector factor-1(APE/Ref-1) a unique target for the prevention and treatment of human melanoma.
Melanoma
Arsenic and ultraviolet radiation exposure: melanoma in a New Mexico non-Hispanic white population.
Melanoma
Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.
Melanoma
LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
Melanoma
MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1.
Melanoma
Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol.
Melanoma
Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.
Melanoma
Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients.
Melanoma
Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.
Melanoma
Targeting Nitric Oxide Signaling with nNOS Inhibitors As a Novel Strategy for the Therapy and Prevention of Human Melanoma.
Memory Disorders
Effect of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats.
Mesothelioma
Formation of the Nitrative DNA Lesion 8-nitroguanine is Associated with Asbestos Contents in Human Lung Tissues: A Pilot Atudy.
Mesothelioma
Identification of Redox-Sensitive Transcription Factors as Markers of Malignant Pleural Mesothelioma.
Mouth Neoplasms
Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan.
Multiple Myeloma
Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma.
Multiple Myeloma
Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.
Multiple Sclerosis
Thioredoxin-1, redox factor-1 and thioredoxin-interacting protein, mRNAs are differentially expressed in Multiple Sclerosis patients exposed and non-exposed to interferon and immunosuppressive treatments.
Myelodysplastic Syndromes
Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies.
Myocardial Infarction
[Serial assessment of right ventricular function in the acute and convalescent stages after successful reperfusion: relationship to infarct-related coronary artery]
Myocardial Ischemia
Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury.
Nasopharyngeal Carcinoma
Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China.
Neoplasm Metastasis
APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival.
Neoplasm Metastasis
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma.
Neoplasm Metastasis
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Neoplasm Metastasis
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged.
Neoplasm Metastasis
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Neoplasm Metastasis
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Neoplasm Metastasis
Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.
Neoplasm Metastasis
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT.
Neoplasm Metastasis
LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
Neoplasm Metastasis
Prediction of Lymph Node Metastases in Gastric Cancer by Serum APE1 Expression.
Neoplasm Metastasis
Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma.
Neoplasm Metastasis
Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients.
Neoplasm Metastasis
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
Neoplasm Metastasis
The expression profile and prognostic value of APE/Ref-1 and NPM1 in high-grade serous ovarian adenocarcinoma.
Neoplasm Metastasis
The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression.
Neoplasms
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
Neoplasms
A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China.
Neoplasms
A reagentless electrochemiluminescent immunosensor for apurinic/apyrimidinic endonuclease 1 detection based on the new Ru(bpy)3(2+)/bi-arginine system.
Neoplasms
Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers.
Neoplasms
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Neoplasms
Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.
Neoplasms
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Neoplasms
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Neoplasms
Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer.
Neoplasms
Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer.
Neoplasms
Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1).
Neoplasms
APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival.
Neoplasms
APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts.
Neoplasms
APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions.
Neoplasms
APE1/Ref-1 enhances DNA binding activity of mutant p53 in a redox-dependent manner.
Neoplasms
Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression.
Neoplasms
APEX nuclease (multifunctional DNA repair enzyme) 1 gene Asp148Glu polymorphism and cancer risk: a meta-analysis involving 58 articles and 48903 participants.
Neoplasms
APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas.
Neoplasms
APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival.
Neoplasms
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study.
Neoplasms
Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells.
Neoplasms
Apurinic apyrimidinic endonuclease/redox effector factor 1 immunoreactivity and grading in hepatocellular carcinoma risk of relapse after liver transplantation.
Neoplasms
Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy.
Neoplasms
Apurinic/apyrimidinic endonuclease 1 (APE1) is overexpressed in malignant transformation of salivary gland pleomorphic adenoma.
Neoplasms
Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor ?-dependent manner in human osteosarcoma.
Neoplasms
Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages.
Neoplasms
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma.
Neoplasms
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Neoplasms
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.
Neoplasms
Apurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-?B-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue.
Neoplasms
Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2.
Neoplasms
Apurinic/apyrimidinic endonuclease1/redox factor-1 inhibits monocyte adhesion in endothelial cells.
Neoplasms
Association between apurinic/apyrimidinic endonuclease 1 rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects.
Neoplasms
Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization.
Neoplasms
Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.
Neoplasms
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Neoplasms
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.
Neoplasms
Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1? interaction in lung cancer.
Neoplasms
Clinical implications of APEX1 and Jagged1 as chemoresistance factors in biliary tract cancer.
Neoplasms
Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models.
Neoplasms
Cytoplasmic Ape1 Expression Elevated by p53 Aberration May Predict Survival and Relapse in Resected Non-Small Cell Lung Cancer.
Neoplasms
Cytoplasmic APE1 promotes resistance response in osteosarcoma patients with cisplatin treatment.
Neoplasms
Cytoplasmic localization and redox cysteine residue of APE1/Ref-1 are associated with its anti-inflammatory activity in cultured endothelial cells.
Neoplasms
Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability.
Neoplasms
Demethyltransferase AlkBH1 substrate diversity and relationship to human diseases.
Neoplasms
Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.
Neoplasms
Differential expression of APE1 in hepatocellular carcinoma and the effects on proliferation and apoptosis of cancer cells.
Neoplasms
Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase.
Neoplasms
Disorder of G2-M Checkpoint Control in Aniline-Induced Cell Proliferation in Rat Spleen.
Neoplasms
DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors.
Neoplasms
DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in oral tongue squamous cell carcinoma.
Neoplasms
DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.
Neoplasms
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Neoplasms
Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression.
Neoplasms
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
Neoplasms
Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma.
Neoplasms
Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate.
Neoplasms
Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes.
Neoplasms
Experimental study enhancing the chemosensitivity of multiple myeloma to melphalan by using a tissue-specific APE1-silencing RNA expression vector.
Neoplasms
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours.
Neoplasms
Expression and prognostic significance of APE1/Ref-1 and NPM1 proteins in high-grade ovarian serous cancer.
Neoplasms
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Neoplasms
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Neoplasms
Expression of the human apurinic endonuclease gene (ape) in normal and malignant-tissues.
Neoplasms
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.
Neoplasms
Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.
Neoplasms
Functional, genetic and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas.
Neoplasms
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Neoplasms
Germline variations of apurinic/apyrimidinic endonuclease 1 (APEX1) detected in female breast cancer patients.
Neoplasms
Graphene Quantum Dot-Based Nanocomposites for Diagnosing Cancer Biomarker APE1 in Living Cells.
Neoplasms
Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters.
Neoplasms
HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy.
Neoplasms
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.
Neoplasms
Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer.
Neoplasms
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
Neoplasms
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.
Neoplasms
Identification and Characterization of Human Apurinic/Apyrimidinic Endonuclease-1 Inhibitors.
Neoplasms
Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.
Neoplasms
Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking.
Neoplasms
Identification of Redox-Sensitive Transcription Factors as Markers of Malignant Pleural Mesothelioma.
Neoplasms
Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells.
Neoplasms
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT.
Neoplasms
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1).
Neoplasms
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Neoplasms
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.
Neoplasms
Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.
Neoplasms
Loss of redox factor 1 decreases NF-kappaB activity and increases susceptibility of endothelial cells to apoptosis.
Neoplasms
Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1.
Neoplasms
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
Neoplasms
miR-296-3p targets APEX1 to suppress cell migration and invasion of non-small-cell lung cancer.
Neoplasms
Multifunctional DNA nanocage with CdTe quantum dots for fluorescence detection of human 8-oxoG DNA glycosylase 1 and doxorubicin delivery to cancer cells.
Neoplasms
Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to ?-irradiation.
Neoplasms
Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol.
Neoplasms
Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome.
Neoplasms
Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-kappab-independent and -dependent pathways.
Neoplasms
Predicting chemosensitivity in osteosarcoma prior to chemotherapy: An investigational study of biomarkers with immunohistochemistry.
Neoplasms
Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas.
Neoplasms
Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer.
Neoplasms
Prognostic Significance of Human Apurinic/Apyrimidinic Endonuclease (APE/Ref-1) Expression in Rectal Cancer Treated With Preoperative Radiochemotherapy.
Neoplasms
Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival.
Neoplasms
Quantitative proteomics reveal up-regulated protein expression of the SET complex associated with hepatocellular carcinoma.
Neoplasms
Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells.
Neoplasms
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells.
Neoplasms
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.
Neoplasms
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target.
Neoplasms
Regulation of HIF1? under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual-Targeting in Patient-Derived 3D Pancreatic Cancer Models.
Neoplasms
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.
Neoplasms
Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis.
Neoplasms
Repair of oxidative DNA damage and cancer - recent progress in DNA base excision repair.
Neoplasms
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.
Neoplasms
Ruguo key genes and tumor driving factors identification of bladder cancer based on the RNA-seq profile.
Neoplasms
Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
Neoplasms
Signal-on electrochemical immunoassay for APE1 using ionic liquid doped Au nanoparticle/graphene as a nanocarrier and alkaline phosphatase as enhancer.
Neoplasms
Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.
Neoplasms
Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation.
Neoplasms
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.
Neoplasms
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.
Neoplasms
The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.
Neoplasms
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target.
Neoplasms
The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies.
Neoplasms
The Effect of Glutathione Peroxidase-1 Knockout on Anticancer Drug Sensitivities and Reactive Oxygen Species in Haploid HAP-1 Cells.
Neoplasms
The extracellular role of Ref-1 as anti-inflammatory function in lipopolysaccharide-induced septic mice.
Neoplasms
The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y-box-binding protein-1 overexpressing tumor cells.
Neoplasms
The redox function of apurinic/apyrimidinic endonuclease 1 as key modulator in photodynamic therapy.
Neoplasms
Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo.
Neoplasms
Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1.
Neoplasms
Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis.
Neoplasms
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment.
Neoplasms
Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis.
Neoplasms
[Effects of beech dust extract on lipid peroxidation and expression of ref-1 gene of mouse lung tissue]
Neoplasms, Germ Cell and Embryonal
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Neural Tube Defects
Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.
Neuroblastoma
Ape1/Ref-1 Stimulates GDNF/GFRalpha1-mediated Downstream Signaling and Neuroblastoma Proliferation.
Neuroblastoma
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study.
Neuroblastoma
Differential Expression of Redox Factor-1 Associated with Beta-Amyloid-Mediated Neurotoxicity.
Neuroblastoma
Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against A?25-35 -induced neurotoxicity in human neuroblastoma cells.
Neuroblastoma
Preconditioning-mediated neuroprotection: role of nitric oxide, cGMP, and new protein expression.
Neuroblastoma
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
Neuroblastoma
Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases.
Neurodegenerative Diseases
Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression.
Neurodegenerative Diseases
Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei.
Neuroectodermal Tumors, Primitive
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Neurofibrosarcoma
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours.
Neuroinflammatory Diseases
Apurinic/apyrimidinic endonuclease 1 is a key modulator of aluminum-induced neuroinflammation.
Neutropenia
APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.
Nevus
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Odontogenic Cysts
Immunoexpression of DNA base excision repair and nucleotide excision repair proteins in ameloblastomas, syndromic and non-syndromic odontogenic keratocysts and dentigerous cysts.
Osteosarcoma
APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival.
Osteosarcoma
Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells.
Osteosarcoma
Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor ?-dependent manner in human osteosarcoma.
Osteosarcoma
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
Osteosarcoma
LncRNA Linc00511 promotes osteosarcoma cell proliferation and migration through sponging miR-765.
Osteosarcoma
miR-513a-5p regulates radiosensitivity of osteosarcoma by targeting human apurinic/apyrimidinic endonuclease.
Osteosarcoma
The regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer.
Ovarian Neoplasms
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor.
Ovarian Neoplasms
Apurinic/apyrimidinic endonuclease 1 polymorphisms are associated with ovarian cancer susceptibility in a Chinese population.
Ovarian Neoplasms
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.
Ovarian Neoplasms
Silencing of Apurinic/Apyrimidinic Endonuclease 1 Inhibits the Growth and Migration in Ovarian Cancer Cell via Activator-Protein-1 Signaling.
Ovarian Neoplasms
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
Pancreatic Neoplasms
Ape1 regulates WNT/?-catenin signaling through its redox functional domain in pancreatic cancer cells.
Pancreatic Neoplasms
Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression.
Pancreatic Neoplasms
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
Pancreatic Neoplasms
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.
Pancreatic Neoplasms
Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models.
Pancreatic Neoplasms
Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro.
Pancreatic Neoplasms
Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.
Pancreatic Neoplasms
Genetic characteristics and prognostic implications of m1A regulators in pancreatic cancer.
Pancreatic Neoplasms
Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.
Pancreatic Neoplasms
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target.
Pancreatic Neoplasms
Regulation of HIF1? under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual-Targeting in Patient-Derived 3D Pancreatic Cancer Models.
Pancreatic Neoplasms
Small interfering RNA against the apurinic or apyrimidinic endonuclease enhances the sensitivity of human pancreatic cancer cells to gemcitabine in vitro.
Pancreatic Neoplasms
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration.
Papilloma, Inverted
Expression Pattern of Apurinic/Apyrimidinic Endonuclease in Sinonasal Squamous Cell Carcinoma.
Paralysis
Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.
Periodontitis
The ATC/TTC haplotype in the Interleukin 8 gene in response to Gram-negative bacteria: A pilot study.
Persistent Infection
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Pheochromocytoma
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
Photosensitivity Disorders
Increased base change mutations at G:C pairs in Escherichia coli deficient in endonuclease III and VIII.
Plasmacytoma
Analysis of cleavage products of DNA repair enzymes and other nucleases. Characterization of an apurinic/apyrimidinic specific endonuclease from mouse plasmacytoma cells.
Pneumonia
A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy.
Pneumonia
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
Pneumonia
Genistein Alleviates Radiation-Induced Pneumonitis by Depressing Ape1/Ref-1 Expression to Down-regulate Inflammatory Cytokines.
Pneumonia
[Correlations between Ape1/Ref-1, ICAM-1 and IL-17A Levels in Serum and Radiation Pneumonitis for Local Advanced Non-small Cell Lung Cancer Patients].
Pre-Eclampsia
Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction.
Pre-Eclampsia
Polymorphisms in DNA repair genes (APEX1, XPD, XRCC1 and XRCC3) and risk of preeclampsia in a Mexican mestizo population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.
Prostatic Intraepithelial Neoplasia
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
Prostatic Neoplasms
APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells.
Prostatic Neoplasms
Apurinic/apyrimidinic endonuclease 1 (APE1/Ref-1) overexpression is an independent prognostic marker in prostate cancer without TMPRSS2:ERG fusion.
Prostatic Neoplasms
Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis.
Prostatic Neoplasms
Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer.
Prostatic Neoplasms
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Prostatic Neoplasms
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
Prostatic Neoplasms
Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells.
Prostatic Neoplasms
Relationship between XPD, RAD51, and APEX1 DNA repair genotypes and prostate cancer risk in the male population of Rio de Janeiro, Brazil.
Prostatic Neoplasms
Retraction: Down-regulation of Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Expression by Soy Isoflavones Enhances Prostate Cancer Radiotherapy In vitro and In vivo.
Pulmonary Disease, Chronic Obstructive
Genetic Polymorphisms of X-ray Repair Cross-Complementing Group 1 and Apurinic/Apyrimidinic Endonuclease-1 in Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Identification of APEX2 as an oncogene in liver cancer.
Radiation Pneumonitis
Clinical value of serum Ape1/Ref-1 combined with TGF-?1 monitoring in predicting the occurrence of radiation pneumonitis (RP) in non-small cell lung cancer patients.
Radiation Pneumonitis
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
Radiation Pneumonitis
[Correlations between Ape1/Ref-1, ICAM-1 and IL-17A Levels in Serum and Radiation Pneumonitis for Local Advanced Non-small Cell Lung Cancer Patients].
Rectal Neoplasms
Prognostic Significance of Human Apurinic/Apyrimidinic Endonuclease (APE/Ref-1) Expression in Rectal Cancer Treated With Preoperative Radiochemotherapy.
Renal Insufficiency, Chronic
ALKBH1 reduces DNA N6-methyladenine to allow for vascular calcification in chronic kidney disease.
Renal Insufficiency, Chronic
APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.
Reperfusion Injury
Expression of redox factor-1 in early injury period after liver transplantation in rat model.
Reperfusion Injury
Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury.
Retinal Neovascularization
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.
Retinoblastoma
Dysregulation of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in advanced retinoblastoma.
Retinoblastoma
Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control.
Retinoblastoma
Role and potential targeting of hepatic apurinic/apyrimidinic endonuclease-1 and cyclin-dependent kinase-4 in hepatocellular carcinoma.
Sarcoma
APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival.
Seizures
Induction of DNA repair proteins, Ref-1 and XRCC1, in adult rat brain following kainic acid-induced seizures.
Seminoma
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Sepsis
Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats.
Small Cell Lung Carcinoma
Upregulation of APE/ref-1 in recurrence stage I, non small cell lung cancer.
Smooth Muscle Tumor
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Spinal Cord Injuries
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells.
Spinal Cord Ischemia
Oxidative damage and reduction of redox factor-1 expression after transient spinal cord ischemia in rabbits.
Squamous Cell Carcinoma of Head and Neck
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Association between polymorphisms in genes related to DNA base-excision repair with risk and prognosis of oropharyngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in oral tongue squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Predictive value of genetic variants XRCC1 rs1799782, APEX1 rs1760944, and MUTYH rs3219489 for adjuvant concurrent chemoradiotherapy outcomes in oral squamous cell carcinoma patients.
Squamous Cell Carcinoma of Head and Neck
The impact of apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) on treatment response and survival in oral squamous cell carcinoma.
Stomach Neoplasms
Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population.
Stomach Neoplasms
Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils.
Stomach Neoplasms
Clinical Significance of Jagged-1 Activated by APEX1 as a Chemoresistance Factor in Advanced Gastric Cancer.
Stomach Neoplasms
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Stomach Neoplasms
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Stomach Neoplasms
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Stomach Neoplasms
Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.
Stomach Neoplasms
MiRNA-339-5p suppresses the malignant development of gastric cancer via targeting ALKBH1.
Stomach Neoplasms
Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).
Stomach Neoplasms
Prediction of Lymph Node Metastases in Gastric Cancer by Serum APE1 Expression.
Stomach Neoplasms
Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer.
Stroke
A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China.
Stroke
APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.
Stroke
Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.
Supranuclear Palsy, Progressive
Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.
Teratoma
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Testicular Neoplasms
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.
Thrombocythemia, Essential
Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyurea.
Thrombosis
Ref-1 protects against FeCl3-induced thrombosis and tissue factor expression via the GSK3?-NF-?B pathway.
Thyroid Neoplasms
APE/Ref-1 is increased in nuclear fractions of human thyroid hyperfunctioning nodules.
Thyroid Neoplasms
Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway.
Thyroid Nodule
APE/Ref-1 is increased in nuclear fractions of human thyroid hyperfunctioning nodules.
Toxoplasmosis, Ocular
Association between ocular toxoplasmosis and APEX1 and MYD88 polymorphism.
Triple Negative Breast Neoplasms
Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation.
Triple Negative Breast Neoplasms
Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo.
Tuberculosis
Crystal structure of the apurinic/apyrimidinic endonuclease IV from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer.
Urinary Bladder Neoplasms
Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer.
Urinary Bladder Neoplasms
APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis.
Urinary Bladder Neoplasms
APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.
Urinary Bladder Neoplasms
Association of nineteen polymorphisms from seven DNA repair genes and the risk for bladder cancer in Gansu province of China.
Urinary Bladder Neoplasms
ERCC1 and XRCC1 expression predicts survival in bladder cancer patients receiving combined trimodality therapy.
Urinary Bladder Neoplasms
Genetic variation in the base excision repair pathway and bladder cancer risk.
Urinary Bladder Neoplasms
High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.
Urinary Bladder Neoplasms
Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India.
Urinary Bladder Neoplasms
Ruguo key genes and tumor driving factors identification of bladder cancer based on the RNA-seq profile.
Uterine Cervical Neoplasms
Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population.
Uterine Cervical Neoplasms
Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.
Uterine Cervical Neoplasms
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Uterine Cervical Neoplasms
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT.
Vascular Calcification
ALKBH1 reduces DNA N6-methyladenine to allow for vascular calcification in chronic kidney disease.
Vascular Calcification
APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.
Vascular System Injuries
Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice.
Virus Diseases
Exploiting the molecular basis of age and gender differences in outcomes of SARS-CoV-2 infections.
Vitamin E Deficiency
Suppression of steroidogenesis and activator protein-1 transcription factor activity in rat adrenals by vitamin E deficiency-induced chronic oxidative stress.
Vitiligo
Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/Apyrimidinic Endonuclease 1.
Xeroderma Pigmentosum
An altered apurinic DNA endonuclease activity in group A and group D xeroderma pigmentosum fibroblasts.
Xeroderma Pigmentosum
Apurinic DNA endonuclease activities in repair-deficient human cell lines.
Xeroderma Pigmentosum
Association Between Polymorphisms of DNA Repair Genes and Risk of Schizophrenia.
Xeroderma Pigmentosum
DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors.
Xeroderma Pigmentosum
Implication of mammalian ribosomal protein S3 in the processing of DNA damage.
Xeroderma Pigmentosum
Poly(adenosine diphosphoribose) synthesis in ultraviolet-irradiated xeroderma pigmentosum cells reconstituted with Micrococcus luteus UV endonuclease.
Xeroderma Pigmentosum
Xeroderma pigmentosum fibroblasts of the D group lack an apurinic DNA endonuclease species with a low apparent Km.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). O29675_ARCFU
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
257
0
29757
TrEMBL
-
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
V217G variant is crystallized with decamer dsDNA molecule, and the three-dimensional structure is determined to 1.7 A resolution
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
F200S
site-directed mutagenesis, by expanding the size of the binding pocket the unspecific endonucleolytic activity is increased
F200S/W215S
site-directed mutagenesis, by expanding the size of the binding pocket the unspecific endonucleolytic activity is increased
V217G
site-directed mutagenesis, by expanding the size of the binding pocket the unspecific endonucleolytic activity is increased
W215S
site-directed mutagenesis, by expanding the size of the binding pocket the unspecific endonucleolytic activity is increased
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
biotechnology
is frequently used in gene technology due to its strong exonucleolytic activity
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schmiedel, R.; Kuettner, E.B.; Keim, A.; Straeter, N.; Greiner-Stoeffele, T.
Structure and function of the abasic site specificity pocket of an AP endonuclease from Archaeoglobus fulgidus
DNA Repair
8
219-231
2009
Archaeoglobus fulgidus (O29675), Archaeoglobus fulgidus
brenda
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Release 2023.1 (January 2023)
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