EC Number   |
Metals/Ions |
Reference |
|---|
   4.2.99.18 | Ca2+ |
optimal concentration at 5-30 mM, only 50% activity at 40 mM |
648668 |
| 4.2.99.18 | Ca2+ |
presence of 1 or 5 mM Ca2+ causes much less efficient stimulation of HpXth's AP site cleavage activity as compared to Mg2+ or Mn2+ |
749127 |
| 4.2.99.18 | Ca2+ |
stimulates |
648635 |
| 4.2.99.18 | Co2+ |
0.1-1.0 mM, strong stimulation of all DNA repair activities |
730783 |
| 4.2.99.18 | Co2+ |
CoCl2 (500 microM) is essential for AP endonuclease assay. Effects of Co on APE/Ref-1 are concentration dependent |
690475 |
| 4.2.99.18 | Co2+ |
stimulation |
648624 |
| 4.2.99.18 | Cu2+ |
activates at 0.01 mM, inhibits at 0.1 mM |
749127 |
| 4.2.99.18 | Fe |
pro-inflammatory activity of iron in the lung injury, at least in part, because of its induction of APE/Ref-1 |
690475 |
| 4.2.99.18 | Fe2+ |
0.1-1.0 mM, strong stimulation of all DNA repair activities |
730783 |
| 4.2.99.18 | Fe2+ |
activates at 0.01 mM, inhibits at 0.1 mM |
749127 |
