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Information on EC 4.2.3.B26 - sclarene synthase and Organism(s) Kitasatospora griseola and UniProt Accession Q9AJE3

for references in articles please use BRENDA:EC4.2.3.B26
preliminary BRENDA-supplied EC number
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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.B26 sclarene synthase
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This record set is specific for:
Kitasatospora griseola
UNIPROT: Q9AJE3 not found.
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The taxonomic range for the selected organisms is: Kitasatospora griseola
The expected taxonomic range for this enzyme is: Kitasatospora griseola
Synonyms
Cyc2, diterpene cyclase-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diterpene cyclase-2
ambiguous
SYSTEMATIC NAME
IUBMB Comments
(+)-copalyl diphosphate diphosphate-lyase (sclarene-forming)
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-copalyl diphosphate
sclarene + diphosphate
show the reaction diagram
-
single product, yield about 50%. Cyc2 does not catalyze further cyclization reaction of (+)-copalyl diphosphate
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
presence is essential for enzymic activity
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CYC2_KITGR
311
0
34773
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakano, C.; Hoshino, T.; Sato, T.; Toyomasu, T.; Dairi, T.; Sassa, T.
Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates
Tetrahedron Lett.
51
125-128
2010
Kitasatospora griseola (Q9AJE3)
-
Manually annotated by BRENDA team