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Information on EC 4.2.3.192 - labda-7,13(16),14-triene synthase and Organism(s) Streptomyces clavuligerus and UniProt Accession B5GRC8

for references in articles please use BRENDA:EC4.2.3.192
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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.192 labda-7,13(16),14-triene synthase
IUBMB Comments
Isolated from the bacterium Streptomyces clavuligerus.
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This record set is specific for:
Streptomyces clavuligerus
UNIPROT: B5GRC8
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The taxonomic range for the selected organisms is: Streptomyces clavuligerus
The expected taxonomic range for this enzyme is: Streptomyces clavuligerus
Synonyms
sclav_p0491, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SCLAV_p0491
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(13E)-labda-7,13-dienyl-diphosphate diphosphate-lyase (labda-7,13(16),14-triene-forming)
Isolated from the bacterium Streptomyces clavuligerus.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
show the reaction diagram
-
-
-
?
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
show the reaction diagram
-
-
-
?
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
in an engineered Streptomyces host, labda-8(17),13(16),14-triene is generated by coexpression of SCLAV_p0491 and diterpene synthase CldB
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LATES_STRCL
343
0
37335
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli and in an engineered Streptomyces host.Recombinant SCLAV_p0490 forms insoluble proteins
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamada, Y.; Komatsu, M.; Ikeda, H.
Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms
J. Antibiot.
69
515-523
2016
Streptomyces clavuligerus (B5GRC8), Streptomyces clavuligerus, Streptomyces clavuligerus DSM 738 (B5GRC8)
Manually annotated by BRENDA team