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Literature summary for 4.2.3.192 extracted from

  • Yamada, Y.; Komatsu, M.; Ikeda, H.
    Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms (2016), J. Antibiot., 69, 515-523 .
    View publication on PubMed
Search for more literature for 4.2.3.192

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and in an engineered Streptomyces host.Recombinant SCLAV_p0490 forms insoluble proteins Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-copalyl diphosphate Streptomyces clavuligerus
-
 labda-8(17),13(16),14-triene + diphosphate
-
 ?
(+)-copalyl diphosphate Streptomyces clavuligerus DSM 738
-
 labda-8(17),13(16),14-triene + diphosphate
-
 ?
labda-7,13-dienyl diphosphate Streptomyces clavuligerus
-
 labda-7,13(16),14-triene + diphosphate
-
 ?
labda-7,13-dienyl diphosphate Streptomyces clavuligerus DSM 738
-
 labda-7,13(16),14-triene + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus B5GRC8
-
-
Streptomyces clavuligerus DSM 738 B5GRC8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-copalyl diphosphate
-
 Streptomyces clavuligerus labda-8(17),13(16),14-triene + diphosphate
-
 ?
(+)-copalyl diphosphate
-
 Streptomyces clavuligerus DSM 738 labda-8(17),13(16),14-triene + diphosphate
-
 ?
labda-7,13-dienyl diphosphate
-
 Streptomyces clavuligerus labda-7,13(16),14-triene + diphosphate
-
 ?
labda-7,13-dienyl diphosphate
-
 Streptomyces clavuligerus DSM 738 labda-7,13(16),14-triene + diphosphate
-
 ?
additional information the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16 Streptomyces clavuligerus ?
-
 ?
additional information the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16 Streptomyces clavuligerus DSM 738 ?
-
 ?

Synonyms

Synonyms Comment Organism
SCLAV_p0491
-
 Streptomyces clavuligerus

General Information

General Information Comment Organism
physiological function in an engineered Streptomyces host, labda-8(17),13(16),14-triene is generated by coexpression of SCLAV_p0491 and diterpene synthase CldB Streptomyces clavuligerus