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Synonyms
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SCLAV_p0491
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(13E)-labda-7,13-dienyl diphosphate = labda-7,13(16),14-triene + diphosphate
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(13E)-labda-7,13-dienyl-diphosphate diphosphate-lyase (labda-7,13(16),14-triene-forming)
Isolated from the bacterium Streptomyces clavuligerus.
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(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
additional information
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(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
Substrates: -
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(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
Substrates: -
?
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
Substrates: -
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labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
Substrates: -
?
additional information
?
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Substrates: the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16
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additional information
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Substrates: the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16
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additional information
?
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Substrates: the ionization of (+)-copalyl diphosphate or labda-7,13-dienyl diphosphate is initiated by the removal of diphosphate, and the resultant cation is then quenched by the deprotonation at H-16
?
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(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
Substrates: -
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(+)-copalyl diphosphate
labda-8(17),13(16),14-triene + diphosphate
Substrates: -
?
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
Substrates: -
?
labda-7,13-dienyl diphosphate
labda-7,13(16),14-triene + diphosphate
Substrates: -
?
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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physiological function
in an engineered Streptomyces host, labda-8(17),13(16),14-triene is generated by coexpression of SCLAV_p0491 and diterpene synthase CldB
physiological function
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in an engineered Streptomyces host, labda-8(17),13(16),14-triene is generated by coexpression of SCLAV_p0491 and diterpene synthase CldB
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LATES_STRCL
343
0
37335
Swiss-Prot
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expression in Escherichia coli and in an engineered Streptomyces host.Recombinant SCLAV_p0490 forms insoluble proteins
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Yamada, Y.; Komatsu, M.; Ikeda, H.
Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms
J. Antibiot.
69
515-523
2016
Streptomyces clavuligerus (B5GRC8), Streptomyces clavuligerus, Streptomyces clavuligerus DSM 738 (B5GRC8)
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