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Enzyme Nomenclature
Information on EC 4.2.3.162 - (-)-alpha-amorphene synthase
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The expected taxonomic range for this enzyme is: Streptomyces viridochromogenes
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EC NUMBER 
COMMENTARY 
4.2.3.162
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RECOMMENDED NAME
GeneOntology No.
(-)-alpha-amorphene synthase
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-alpha-amorphene-forming)
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
(-)-alpha-amorphene + diphosphate
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(-)-alpha-amorphene i.e. (1S,4aR,8aS)-4,7-dimethyl-1-(propan-2-yl)-1,2,4a,5,6,8a-hexahydronaphthalene. Initial 1,6-cyclisation
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-
?
(2E,6E)-farnesyl diphosphate
(-)-alpha-amorphene + diphosphate
-
(-)-alpha-amorphene i.e. (1S,4aR,8aS)-4,7-dimethyl-1-(propan-2-yl)-1,2,4a,5,6,8a-hexahydronaphthalene. Initial 1,6-cyclisation. Incubations with geranyl diphosphate and geranylgeranyl diphosphate gives no products
-
-
?
(2E,6E)-farnesyl diphosphate
(-)-alpha-amorphene + diphosphate
-
(-)-alpha-amorphene i.e. (1S,4aR,8aS)-4,7-dimethyl-1-(propan-2-yl)-1,2,4a,5,6,8a-hexahydronaphthalene. Initial 1,6-cyclisation. Incubations with geranyl diphosphate and geranylgeranyl diphosphate gives no products
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-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
(-)-alpha-amorphene + diphosphate
-
(-)-alpha-amorphene i.e. (1S,4aR,8aS)-4,7-dimethyl-1-(propan-2-yl)-1,2,4a,5,6,8a-hexahydronaphthalene. Initial 1,6-cyclisation
-
-
?
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.3.162)
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