Information on EC 4.2.3.100 - bicyclogermacrene synthase

for references in articles please use BRENDA:EC4.2.3.100
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The expected taxonomic range for this enzyme is: Origanum vulgare

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EC NUMBER
COMMENTARY hide
4.2.3.100
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RECOMMENDED NAME
GeneOntology No.
bicyclogermacrene synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming)
The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
bicyclogermacrene + diphosphate
show the reaction diagram
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bicyclogermacrene is the major product in the presence of Mn2+, minor products are (E)-beta-caryophyllene, alpha-humulene, alloaromadendrene, and an unknown sesquiterpene
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?
additional information
?
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geraniol is the main product from geranyl diphosphate in the presence of either Mn2+ or Mg2+, minor products are myrcene, limonene, gamma-terpinene, cis-ocimene, trans-beta-ocimene, terpinolene, linalool, and alpha-terpineol
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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in the presence of Mg2+, the enzyme produces bicyclogermacrene and alloaromadendrene as main products
Mn2+
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in the presence of Mn2+, the enzyme produces mainly bicyclogermacrene
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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peltate glandular trichome
Manually annotated by BRENDA team
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.3.100)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)