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Information on EC 4.2.3.100 - bicyclogermacrene synthase for references in articles please use BRENDA:EC4.2.3.100Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Origanum vulgare
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bicyclogermacrene synthase
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(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate
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(2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming)
The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.
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brenda
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(2E,6E)-farnesyl diphosphate
bicyclogermacrene + diphosphate
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bicyclogermacrene is the major product in the presence of Mn2+, minor products are (E)-beta-caryophyllene, alpha-humulene, alloaromadendrene, and an unknown sesquiterpene
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additional information
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geraniol is the main product from geranyl diphosphate in the presence of either Mn2+ or Mg2+, minor products are myrcene, limonene, gamma-terpinene, cis-ocimene, trans-beta-ocimene, terpinolene, linalool, and alpha-terpineol
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Mg2+
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in the presence of Mg2+, the enzyme produces bicyclogermacrene and alloaromadendrene as main products
Mn2+
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in the presence of Mn2+, the enzyme produces mainly bicyclogermacrene
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brenda
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peltate glandular trichome
brenda
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expressed in Escherichia coli BL21(DE3) cells
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TPS5_PHYDL
565
66477
Swiss-Prot
BCGS_ORIVU
555
64443
Swiss-Prot
A0A2G9FW84_9LAMI
283
33228
TrEMBL
A0A2G9I4W5_9LAMI
561
65295
TrEMBL
A0A2G9HYY1_9LAMI
547
64369
TrEMBL
A0A2G9HYY7_9LAMI
364
43117
TrEMBL
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Crocoll, C.; Asbach, J.; Novak, J.; Gershenzon, J.; Degenhardt, J.
Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis
Plant Mol. Biol.
73
587-603
2010
Origanum vulgare
brenda
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