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Information on EC 4.1.99.2 - tyrosine phenol-lyase and Organism(s) Fusobacterium nucleatum and UniProt Accession Q8RHM6

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.2 tyrosine phenol-lyase
IUBMB Comments
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
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Fusobacterium nucleatum
UNIPROT: Q8RHM6
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Word Map
The taxonomic range for the selected organisms is: Fusobacterium nucleatum
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
tpl, tyrosine phenol-lyase, tyrosine phenol lyase, beta-tyrosinase, l-tyrosine phenol-lyase, tyrosine-phenol lyase, fn-tpl, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
beta-tyrosinase
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L-tyrosine phenol-lyase
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phenol-lyase, tyrosine
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TPL
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
racemization
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alpha,beta-elimination
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transamination
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-31-8
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