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Information on EC 4.1.1.55 - 4,5-dihydroxyphthalate decarboxylase
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EC Tree
4.1.1.55 4,5-dihydroxyphthalate decarboxylaseSpecify your search results
Word Map
- 4.1.1.55
- protocatechuate
- dioxygenase
-
4,5-dioxygenase
- testosteroni
- sulfitobacter
- marinomonas
-
coast
- seawater
- o-phthalate
- rhodovulum
- alteromonas
- thalassospira
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
Decarboxylase, 4,5-dihydroxyphthalate, DHP decarboxylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Decarboxylase, 4,5-dihydroxyphthalate
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-
-
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DHP decarboxylase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
decarboxylation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)
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CAS REGISTRY NUMBER
COMMENTARY
37290-48-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4,5-Dihydroxyphthalate
?
-
enzyme is involved in o-phthalate catabolism
-
-
?
4,5-Dihydroxyphthalate
?
-
enzyme is involved in o-phthalate catabolism
-
-
?
4,5-Dihydroxyphthalate
?
-
enzyme is involved in o-phthalate catabolism
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4,5-Dihydroxyphthalate
?
-
enzyme is involved in o-phthalate catabolism
-
-
?
4,5-Dihydroxyphthalate
?
-
enzyme is involved in o-phthalate catabolism
-
-
?
4,5-Dihydroxyphthalate
?
-
enzyme is involved in o-phthalate catabolism
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2,4,6-Trinitrobenzene sulfonate
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inhibition is partially prevented by 4,5-dihydroxyphthalate or 4-hydroxyphthalate, 1 mM
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Show AA Sequence and Transmembrane Helices (317 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexamer
tetramer
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
dialysis against distilled water or phosphate buffer, 0.067 M, pH 5.9-8.5, at 0-3°C, results in no appreciable loss of activity. Dialysis for 3-4 days causes about 70% loss of activity
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no inactivation by dialysis against 0.2 mM of either EDTA or o-phenanthroline in 0.05 M Tris-acetate, pH 7.5, containing 0.2 mM dithiothreitol, at 4°C, overnight
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 0.05 M Tris-acetate, pH 7.5, 0.2 mM dithiothreitol, 50% loss of activity after 4 days
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pujar, B.G.; Ribbons, D.W.
Phthalate metabolism in Pseudomonas fluorescens PHK: purification and properties of 4,5-dihydroxyphthalate decarboxylase
Appl. Environ. Microbiol.
49
374-376
1985
Pseudomonas fluorescens, Pseudomonas fluorescens PHK
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Taylor, B.F.; Ribbons, D.W.
Bacterial decarboxylation of o-phthalic acid
Appl. Environ. Microbiol.
46
1276-1281
1983
Comamonas testosteroni, no activity in Bacillus sp., no activity in Bacillus sp. FO
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Nakazawa, T.; Hayashi, E.
Phthalate and 4-hydroxyphthalate metabolism in Pseudomonas testosteroni: purification and properties of 4,5-dihydroxyphthalate decarboxylase
Appl. Environ. Microbiol.
36
264-269
1978
Comamonas testosteroni, Comamonas testosteroni NH1000
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Ribbons, D.W.; Evans, W.C.
Oxidative metabolism of phthalic acid soil Pseudomonads
Biochem. J.
76
310-318
1960
Pseudomonas sp.
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Nakazawa, T.; Hayashi, E.
Phthalate metabolism in Pseudomonas testosteroni: accumulation of 4,5-dihydroxyphthalate by a mutant strain
J. Bacteriol.
131
42-48
1977
Comamonas testosteroni, Comamonas testosteroni NH1000
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Grifoll, M.; Selifonov, S.A.; Chapman, P.J.
Evidence for a novel pathway in the degradation of fluorene by Pseudomonas sp. strain F274
Appl. Environ. Microbiol.
60
2438-2449
1994
Pseudomonas sp., Pseudomonas sp. F274
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Iwaki, H.; Nishimura, A.; Hasegawa, Y.
Isolation and characterization of marine bacteria capable of utilizing phthalate
World J. Microbiol. Biotechnol.
28
1321-1325
2012
Burkholderia cepacia, Pseudomonas putida, Pseudomonas putida NMH102-2, Burkholderia cepacia DBO1 / ATCC 29424
brenda
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