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Information on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP) and Organism(s) Saccharomyces cerevisiae and UniProt Accession P10963

for references in articles please use BRENDA:EC4.1.1.32
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
IUBMB Comments
ITP can act as phosphate donor.
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This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: P10963
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Synonyms
pdc-e2, pepck-c, pep carboxykinase, p-enolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase (gtp), pepck-m, pep-carboxykinase, phosphopyruvate carboxylase, phosphopyruvate carboxykinase, gtp:oxaloacetate carboxy-lyase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GTP:oxaloacetate carboxy-lyase
transphosphorylating, interacts also with ATP, EC 4.1.1.49
PEP carboxykinase
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phosphoenolpyruvate carboxykinase
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carboxykinase, phosphopyruvate (guanosine triphosphate)
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oxaloacetate kinase (decarboxylating, GDP)
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P-enolpyruvate carboxykinase
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PEP carboxykinase
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PEP carboxylase
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PEPCK
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phosphoenolpyruvate carboxykinase
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Phosphoenolpyruvate carboxylase
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phosphoenolpyruvate carboxylase (GTP)
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phosphoenolpyruvic carboxykinase
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phosphoenolpyruvic carboxykinase (GTP)
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phosphoenolpyruvic carboxykinase (inosine triphosphate)
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Phosphoenolpyruvic carboxylase
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phosphoenolpyruvic carboxylase (GTP)
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phosphoenolpyruvic carboxylase (inosine triphosphate)
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phosphopyruvate carboxykinase
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phosphopyruvate carboxylase
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phosphopyruvate carboxylase (GTP)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2
show the reaction diagram
two-step mechanism: phosphorylation followed by decarboxylation, transition state with carbocationic character
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylation
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decarboxylation
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SYSTEMATIC NAME
IUBMB Comments
GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
ITP can act as phosphate donor.
CAS REGISTRY NUMBER
COMMENTARY hide
9013-08-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
show the reaction diagram
interacts also with ATP, EC 4.1.1.49
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?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43000
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2 * 43000, SDS-PAGE
80000
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non-denaturing PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
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2 * 43000, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S252A
side directed mutagenesis
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
mutant PEP carboxykinase
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
mutant plasmid is transformed into the PEP carboxykinase-deficient yeast strain PUK-3B (MATalpha pck ura3)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dhe-Paganon, S.; Magrath, J.; Abeles, R.H.
Mechanism of mevalonate pyrophosphate decarboxylase: evidence for a carbocationic transition state
Biochemistry
33
13355-13362
1994
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Castillo, D.; Sepulveda, C.; Cardemil, E.; Jabalquinto, A.M.
Functional evaluation of serine 252 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase
Biochimie
91
295-299
2008
Saccharomyces cerevisiae (P10963)
Manually annotated by BRENDA team