Information on EC 4.1.1.107 - 3,4-dihydroxyphenylacetaldehyde synthase

for references in articles please use BRENDA:EC4.1.1.107
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.1.107
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RECOMMENDED NAME
GeneOntology No.
3,4-dihydroxyphenylacetaldehyde synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Tyrosine metabolism
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SYSTEMATIC NAME
IUBMB Comments
L-dopa carboxy-lyase (oxidative-deaminating)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-methyl-L-Dopa + O2 + H2O
3,4-dihydroxyphenylacetone + CO2 + NH3 + H2O2
show the reaction diagram
L-Dopa + O2 + H2O
3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-Dopa + O2 + H2O
3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.88 - 1.23
L-Dopa
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
anion exchange column chromatography and gel filtration
Q9VIZ9;
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli ER2566 cells
Q9VIZ9;
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C194S
Q9VIZ9;
the mutant shows about wild type activity
N192H
Q9VIZ9;
the mutant shows increased L-dopa decarboxylase activity compared to the wild type enzyme
Y80F
Q9VIZ9;
the mutant shows about wild type activity