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Disease on EC 3.6.4.B9 - Rad54 translocase and Organism(s) Homo sapiens and UniProt Accession Q92698

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
DNA repair gene polymorphisms and risk of pancreatic cancer.
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.
Adenocarcinoma of Lung
Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma.
The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.
Breast Neoplasms
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Identification of RAD54 homolog B as a promising therapeutic target for breast cancer.
Integrated study of miR-215 promoting breast cancer cell apoptosis by targeting RAD54B.
Loss of heterozygosity in the RAD54B region is not predictive for breast carcinomas.
Polymorphisms in homologous recombination repair genes and the risk and survival of breast cancer.
RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer.
[Analysis of loss of heterozygosity and microsatellite instability RAD52, RAD54 and RAD54B gene and BRCA1 gene mutation in breast cancer]
Carcinogenesis
The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer.
Carcinoma
Concurrent Gain of Oncogenes Drives Choroid Plexus Carcinoma.
Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.
Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker.
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.
Carcinoma, Hepatocellular
Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/?-catenin signaling.
Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Carcinoma, Ovarian Epithelial
Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene.
Carcinoma, Squamous Cell
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.
Cleft Lip
Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate.
Colonic Neoplasms
A role for RAD54B in homologous recombination in human cells.
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
Colorectal Neoplasms
High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients.
Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.
Dermatitis, Contact
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Glioblastoma
CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma.
Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma.
Glioma
Genetic variations in the homologous recombination repair pathway genes modify risk of glioma.
Hyperandrogenism
Replication study of RAD54B and GREB1 polymorphisms and risk of PCOS in Han Chinese.
Leukemia, Lymphocytic, Chronic, B-Cell
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia.
Liver Neoplasms
Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Lung Neoplasms
Knockdown of RAD54B expression reduces cell proliferation and induces apoptosis in lung cancer cells.
Lymphoma
Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies.
Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker.
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
Melanoma
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.
Meningioma
Association of MTHFR, MTRR and RAD54L Gene Variations with Meningioma and Correlation with Tumor's Histopathological Characteristics on Turkish Cohort.
Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker.
Neoplasm Metastasis
Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/?-catenin signaling.
Neoplasms
A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer.
Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/?-catenin signaling.
Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.
E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair.
Effects of tumor-associated mutations on Rad54 functions.
Germline RAD54L with somatic POLE defect implicated in Hypermutation phenotype: case report.
Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma.
Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker.
Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.
Prognostic significance of epigenetic regulatory gene expression in patients with non-small-cell lung cancer.
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer.
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.
The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer.
The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition.
Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes.
YM155 and BIRC5 downregulation induce genomic instability via autophagy-mediated ROS production and inhibition in DNA repair.
Ovarian Neoplasms
A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer.
Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes.
Pancreatic Neoplasms
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
Polycystic Ovary Syndrome
Replication study of RAD54B and GREB1 polymorphisms and risk of PCOS in Han Chinese.
Prostatic Neoplasms
Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer.
Squamous Cell Carcinoma of Head and Neck
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.
Urinary Bladder Neoplasms
E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair.
Werner Syndrome
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.