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Disease on EC 3.6.4.B7 - RadA recombinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Monoclonal antibodies against the Escherichia coli DNA repair protein RadA/Sms.
Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.
Adenocarcinoma
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen.
DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma.
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells.
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage.
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
RAD51 Inhibitor Reverses Etoposide-Induced Genomic Toxicity and Instability in Esophageal Adenocarcinoma Cells.
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma.
Targeting PI3K and RAD51 in Barrett's Adenocarcinoma: Impact on DNA Damage Checkpoints, Expression Profile and Tumor Growth.
[Expression of RAD51 and MAX in pancreatic cancer rats.]
Adenocarcinoma of Lung
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
TP53 and DNA-repair gene polymorphisms genotyping as a low-cost lung adenocarcinoma screening tool.
Adenoma
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
RAD51 protein expression is increased in canine mammary carcinomas.
Adenomatous Polyposis Coli
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Anemia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Astrocytoma
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Ataxia Telangiectasia
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.
Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis.
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance.
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.
Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development.
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health.
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.
Regulation of DNA Damage Response by Estrogen Receptor ?-Mediated Inhibition of Breast Cancer Associated Gene 2.
Targeting PI3K and RAD51 in Barrett's Adenocarcinoma: Impact on DNA Damage Checkpoints, Expression Profile and Tumor Growth.
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Bloom Syndrome
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Critical interaction domains between bloom syndrome protein and RAD51.
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Structural and functional characterization of the N-terminal domain of human Rad51D.
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Bone Marrow Failure Disorders
Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.
PALB2 (partner and localizer of BRCA2).
Brain Neoplasms
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: The role of Rad51.
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
Breast Neoplasms
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.
A homologous recombination defect affects replication-fork progression in mammalian cells.
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers.
A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts.
A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women.
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer.
Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer.
Alternative transcript imbalance underlying breast cancer susceptibility in a family carrying PALB2 c.3201+5G>T.
Analysis of RAD51 polymorphism and BRCA1 mutations in Polish women with breast cancer.
Analysis of the G/C polymorphism in the 5'-untranslated region of the RAD51 gene in breast cancer.
ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.
Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1.
Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients.
Association between RAD51 polymorphism and breast cancer susceptibility: a meta analysis.
Association between the RAD51 135 G>C Polymorphism and Risk of Cancer: A Meta-Analysis of 19,068 Cases and 22,630 Controls.
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.
Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk.
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.
BLM and RAD51 Genes Polymorphism and Susceptibility to Breast Cancer.
BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity.
BRCA2 BRC motifs bind RAD51-DNA filaments.
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡.
Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.
Breast cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland.
BSSV: Bayesian based somatic structural variation identification with whole genome DNA-seq data.
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.
Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity.
Common nonsense mutations in RAD52.
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.
Correction for Gasparini et al., Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Correlation between selected XRCC2, XRCC3 and RAD51 gene polymorphisms and primary breast cancer in women in Pakistan.
CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells.
Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells.
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.
Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer.
DNA Repair Gene Expression and Risk of Locoregional Relapse in Breast Cancer Patients.
DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population.
Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers?
Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer.
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.
Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells.
E2F1-regulated long non-coding RNA RAD51-AS1 promotes cell cycle progression, inhibits apoptosis and predicts poor prognosis in epithelial ovarian cancer.
Effect of RAD51C expression on the chemosensitivity of E?-Myc p19Arf-/- cells and its clinical significance in breast cancer.
Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.
Epidemiology of Breast Cancer in Women.
Evaluation of miRNA-binding-site SNPs of MRE11A, NBS1, RAD51 and RAD52 involved in HRR pathway genes and risk of breast cancer in China.
Exploring the role of BRCA1, BRCA2 and RAD51 as biomarkers for breast cancer.
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.
FIGNL1-containing protein complex is required for efficient homologous recombination repair.
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.
Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells.
Genetic instability and cancer.
Genetic instability in the RAD51 and BRCA1 regions in breast cancer.
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
Genetics polymorphism in DNA repair genes by base excision repair pathway (XRCC1) and homologous recombination (XRCC2 and RAD51) and the risk of breast carcinoma in the Polish population.
Germline BRCA1 mutations and G/C polymorphism in the 5'-untranslated region of the RAD51 gene in Polish women with breast cancer.
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients.
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.
Identification of Rad51 alteration in patients with bilateral breast cancer.
Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.
Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.
Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: The role of Rad51.
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib.
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats.
Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity.
Is RAD51 135G>C polymorphism really associated with breast cancer in general population? Biased design and results lead to inappropriate conclusion.
Jab1/Cops5 contributes to chemoresistance in breast cancer by regulating Rad51.
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy.
Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.
Loss of heterozygosity in the RAD51 and BRCA2 regions in breast cancer.
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress.
MiRNA-binding site functional polymorphisms in DNA repair genes RAD51, RAD52, and XRCC2 and breast cancer risk in Chinese population.
Molecular characterization of a human BRCA2 homolog in Leishmania donovani.
Multigene testing of moderate-risk genes: be mindful of the missense.
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
Need for clarification of data in the recent meta-analysis about RAD51 135G>C polymorphism and breast cancer risk.
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database.
New conflicting results obtained in the subgroup analysis of RAD51 135G>C polymorphism and breast cancer risk.
Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer.
Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.
Polymorphisms in cancer susceptibility genes XRCC1, RAD51 and TP53 and the risk of breast cancer in Serbian women.
Polymorphisms in RAD51 and their relation with breast cancer in Saudi females.
Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk.
Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51.
Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer.
Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.
RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies.
RAD51 135G>C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women.
RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies.
RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis.
RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population.
RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects.
RAD51 135G>C substitution increases breast cancer risk in an ethnic-specific manner: a meta-analysis on 21,236 cases and 19,407 controls.
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects.
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Rad51 paralogs and the risk of unselected breast cancer: A case-control study.
RAD51 polymorphisms and breast cancer risk.
Rad51 supports triple negative breast cancer metastasis.
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.
RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.
Radiosensitization effects of berberine on human breast cancer cells.
Relationship between B-Cell-specific moloney murine leukemia virus integration site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas.
Resveratrol decreases Rad51 expression and sensitizes cisplatin?resistant MCF?7 breast cancer cells.
Same data sources, different pooled analysis result: the ongoing uncertainty in the subgroup analysis of RAD51 135G/C polymorphism and breast cancer risk.
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients.
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.
Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in polish women.
Slug/?-Catenin-Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells.
Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors.
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks.
Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors.
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Taking a Bad Turn: Compromised DNA Damage Response in Leukemia.
Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality.
The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer.
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin.
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer.
The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.
The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.
TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.
Towards rational design of RAD51-targeting prodrugs: platinumIV-artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells.
TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro.
Trajectory and uniqueness of mutational signatures in yeast mutators.
Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.
Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair.
Use of the Rad51 promoter for targeted anti-cancer therapy.
Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.
Variants in DNA double-strand break repair genes and breast cancer susceptibility.
Variation in the RAD51 gene and familial breast cancer.
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.
XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients.
XRCC3 and RAD51 Expression Are Associated with Clinical Factors in Breast Cancer.
[The G/C polymorphism of RAD51 gene in breast cancer]
Carcinogenesis
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Analysis of functional hub genes identifies CDC45 as an oncogene in non-small cell lung cancer - a short report.
Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis.
BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: implications for sister chromatid cohesion, genome stability, and carcinogenesis.
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer.
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Elevated levels of Rad51 recombination protein in tumor cells.
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: Prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis.
Estrogen induces RAD51C expression and localization to sites of DNA damage.
Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.
Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.
Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection.
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.
Progressing from Recurring Tissue Injury to Genomic Instability: A New Mechanism of Neutrophil Pathogenesis.
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.
RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.
RAD51 paralog function in replicative DNA damage and tolerance.
RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis.
RAD51, genomic stability, and tumorigenesis.
Role of Rad51 and DNA repair in cancer: A molecular perspective.
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
The consequences of Rad51 overexpression for normal and tumor cells.
The homologous recombination protein RAD51D protects the genome from large deletions.
The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma.
The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.
[Expression of RAD51 and MAX in pancreatic cancer rats.]
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Carcinoma
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer.
Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells.
Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas.
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients.
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma.
Equivocal association of RAD51 polymorphisms with risk of esophageal squamous cell carcinoma in a Chinese population.
Erratum to: Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Identification of miRNA modulators to PARP inhibitor response.
Impact of RAD51 G135C and XRCC1 Arg399Gln polymorphisms on ovarian carcinoma risk in Serbian women.
Increased expression of human DNA repair genes, XRCC1, XRCC3 and RAD51, in radioresistant human KB carcinoma cell line N10.
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells.
Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells.
Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer.
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism.
Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma.
RAD51 Expression as a Biomarker to Predict Efficacy of Preoperative Therapy and Survival for Esophageal Squamous Cell Carcinoma: A Large-cohort Observational Study (KSCC1307).
Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
RAD51 protein expression is increased in canine mammary carcinomas.
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells.
Susceptibility of XPD and RAD51 Genetic Variants to Carcinoma of Urinary Bladder in North Indian Population.
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma.
The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks.
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.
The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Carcinoma, Hepatocellular
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents.
Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells.
Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation.
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Carcinoma, Non-Small-Cell Lung
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells.
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients.
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.
Downregulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small cell lung cancer cells.
Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms.
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy.
KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma.
Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells.
Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine.
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma.
Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status.
Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells.
Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells.
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.
The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.
Carcinoma, Ovarian Epithelial
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
Carcinoma, Squamous Cell
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas.
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Erratum to: Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism.
Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.
Cardiomyopathies
Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor.
Chagas Disease
Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation.
The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.
Cholangiocarcinoma
Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells.
Chondrosarcoma
Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair.
Chordoma
Radioresistance of chordoma cells is associated with the ATM/ATR pathway, in which RAD51 serves as an important downstream effector.
Choriocarcinoma
Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells.
Cleft Lip
Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.
Cleft Palate
Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.
Cockayne Syndrome
DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.
ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB.
Colonic Neoplasms
A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells.
Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1.
GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells.
Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells.
Mitotic crossover--an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma.
p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line.
The effect of polymorphism in DNA repair genes RAD51 and XRCC2 in colorectal cancer in Turkish population.
The use of olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
Colorectal Neoplasms
A review on role of ATM gene in hereditary transfer of colorectal cancer.
Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.
Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer.
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Evaluation of pharmacodynamic responses to cancer therapeutic agents using DNA damage markers.
Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population.
Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population.
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer.
Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population.
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer-a case control study.
RAD51 135G>C polymorphism and risk of sporadic colorectal cancer in Iranian population.
RAD51 G135C gene polymorphism and risk of colorectal cancer in Kashmir.
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland.
Retraction: Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
The effect of polymorphism in DNA repair genes RAD51 and XRCC2 in colorectal cancer in Turkish population.
The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
The Targeting of MRE11 or RAD51 Sensitizes Colorectal Cancer Stem Cells to CHK1 Inhibition.
XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Gene Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis
[The role of RAD 51 gene polymorphism in patients with colorectal cancer in the Polish subpopulation]
Colorectal Neoplasms, Hereditary Nonpolyposis
Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Corneal Dystrophies, Hereditary
Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy.
Diphtheria
Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.
Use of the Rad51 promoter for targeted anti-cancer therapy.
dna 3'-5' helicase deficiency
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.
DNA Repair-Deficiency Disorders
Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation.
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Endometrial Neoplasms
135G>C and 172G>T polymorphism in the 5' untranslated region of RAD51 and sporadic endometrial cancer risk in Polish women.
Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population.
DNA damage and repair in endometrial cancer in correlation with the hOGG1 and RAD51 genes polymorphism.
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas.
Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors.
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Single nucleotide polymorphisms of RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met homologous recombination repair genes and the risk of sporadic endometrial cancer in Polish women.
Endometriosis
Association Between Impairment of DNA Double Strand Break Repair and Decreased Ovarian Reserve in Patients With Endometriosis.
Esophageal Neoplasms
Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51.
CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer.
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.
Genetic variants of the DNA damage repair genes XRCC4 and RAD51 are associated with susceptibility to esophageal cancer.
Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition.
MiroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative.
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.
[The study of esophageal cancer risk associated with polymorphisms of DNA damage repair genes XRCC4 and RAD51].
Esophageal Squamous Cell Carcinoma
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma.
Equivocal association of RAD51 polymorphisms with risk of esophageal squamous cell carcinoma in a Chinese population.
RAD51 Expression as a Biomarker to Predict Efficacy of Preoperative Therapy and Survival for Esophageal Squamous Cell Carcinoma: A Large-cohort Observational Study (KSCC1307).
Fanconi Anemia
A Japanese patient with RAD51-associated Fanconi anemia.
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.
A tough row to hoe: when replication forks encounter DNA damage.
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
FANCD2 associated with sporadic breast cancer risk.
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Genetic basis of Fanconi anemia.
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Homologous recombination, cancer and the 'RAD51 paradox'.
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1.
Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2.
Isomerization of BRCA1-BARD1 promotes replication fork protection.
PALB2 (partner and localizer of BRCA2).
Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.
RAD51 Gene Family Structure and Function.
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer.
Zalypsis displays preclinical activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.
Fibrosarcoma
Rad51-related changes in global gene expression.
Use of the Rad51 promoter for targeted anti-cancer therapy.
[Expression of RAD51 and MAX in pancreatic cancer rats.]
Fuchs' Endothelial Dystrophy
Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy.
Gastrointestinal Stromal Tumors
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Glioblastoma
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells.
Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma.
Association between RAD 51 rs1801320 and susceptibility to glioblastoma.
CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51.
Cell Cycle Changes after Glioblastoma Stem Cell Irradiation: The Major Role of RAD51.
CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation.
FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA Repair Gene Rad51.
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila.
Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72.
N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression.
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.
Rad51 protein expression and survival in patients with glioblastoma multiforme.
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
Glioma
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells.
Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy.
DNA repair after irradiation in glioma cells and normal human astrocytes.
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation.
In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene.
Integrin ?V?3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.
Polymorphisms of DNA repair genes and risk of glioma.
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor derived cells.
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.
Targeting homologous recombination by pharmacological inhibitors enhances the killing response of glioblastoma cells treated with alkylating drugs.
[RAD51 promotes proliferation and migration of glioblastoma cells and decreases sensitivity of cells to temozolomide].
Head and Neck Neoplasms
Association between RAD51 polymorphisms and susceptibility of head and neck cancer: a meta-analysis.
Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
Association of XRCC3 C722T and RAD51 G135C polymorphisms with head and neck cancer susceptibility in a Polish population.
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.
Genetic variability of Xrcc3 and Rad51 modulates the risk of head and neck cancer.
Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers.
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population" by Sliwinski et al. published in Experimental and Molecular Pathology, 2010 Dec; 89 (3): 358-66.
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population.
Hepatitis
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Hepatitis B
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Hepatitis C
Rad51 Interacts with Non-structural 3 Protein of Hepatitis C Virus and Regulates Viral Production.
Herpes Simplex
HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation.
Rad51 and Rad52 are involved in homologous recombination of replicating herpes simplex virus DNA.
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Histiocytic Sarcoma
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
HIV Infections
Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51.
Hyperparathyroidism, Primary
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Hypersensitivity
A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.
A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
A syngeneic variance library for functional annotation of human variation: application to BRCA2.
Ablation of the Brca1-Palb2 Interaction Phenocopies Fanconi Anemia in Mice.
Atmospheric-pressure plasma jet induces DNA double-strand breaks that require a Rad51-mediated homologous recombination for repair in Saccharomyces cerevisiae.
Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype.
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance.
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.
Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability.
Differential requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana development and DNA damage repair.
Differential roles of XRCC2 in homologous recombinational repair of stalled replication forks.
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Fanconi anemia pathway heterogeneity revealed by cisplatin and oxaliplatin treatments.
Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells.
Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling.
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes.
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.
Regulation of Rad51 function by phosphorylation.
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
The phenotype of FancB-mutant mouse embryonic stem cells.
Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination.
Hypertension
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
Idiopathic Pulmonary Fibrosis
FoxM1-dependent RAD51 and BRCA2 signaling protects idiopathic pulmonary fibrosis fibroblasts from radiation-induced cell death.
Infections
Activation of HIV-1 LTR by Rad51 in microglial cells.
Alterations of DNA damage repair pathways resulting from JCV infection.
Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses.
External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase.
Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection.
Interplay of Rad51 with NF-?B pathway stimulates expression of HIV-1.
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Protection elicited by a replication-defective adenovirus vector expressing the tick-borne encephalitis virus non-structural glycoprotein NS1.
Rad51 activates polyomavirus JC early transcription.
RAD51 G135C genetic polymorphism and their potential role in gastric cancer induced by Helicobacter pylori infection in Bhutan.
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation.
The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.
The recombination mediator RAD51D promotes geminiviral infection.
Infertility
Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
Expression of Rad51 and the histo-morphological evaluation of testis of the sterile male cattle-yak.
Functional analysis of the Drosophila Rad51 gene (spn-A) in repair of DNA damage and meiotic chromosome segregation.
Meiotic Recombination in Arabidopsis Is Catalysed by DMC1, with RAD51 Playing a Supporting Role.
Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.
RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
Infertility, Male
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.
Keratoconus
Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy.
Rare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent.
Laminopathies
Lamin A ?exon9 mutation leads to telomere and chromatin defects but not genomic instability.
Laryngeal Neoplasms
Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population.
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Leiomyoma
Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3).
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Lentivirus Infections
[RAD51 promotes proliferation and migration of glioblastoma cells and decreases sensitivity of cells to temozolomide].
Leukemia
Association between RAD51 gene polymorphism (-135G/C) and susceptibility of myelodysplastic syndrome and acute leukemia: evidence based on a meta-analysis.
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.
Genetic polymorphisms of RAD51, XRCC3 and acute myeloid leukemia risk: a meta-analysis.
MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.
ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization.
PALB2 (partner and localizer of BRCA2).
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Role of the NRP-1-mediated VEGFR2-independent pathway on radiation sensitivity of non-small cell lung cancer cells.
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.
Targeting RAD51 enhances chemosensitivity of adult T?cell leukemia?lymphoma cells by reducing DNA double?strand break repair.
Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia.
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Leukemia, Lymphoid
Attenuating homologous recombination stimulates an AID-induced antileukemic effect.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Leukemia, Myeloid, Acute
135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis.
DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group.
Genetic polymorphisms of RAD51, XRCC3 and acute myeloid leukemia risk: a meta-analysis.
HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia.
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells.
Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.
MicroRNA-107 promotes apoptosis of acute myelocytic leukemia cells by targeting RAD51.
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia.
RAD51 and XRCC3 Gene Polymorphisms and the Risk of Developing Acute Myeloid Leukemia.
RAD51 and XRCC3 polymorphisms: Impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBF?-MYH11(+) acute myeloid leukemia.
Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants.
Leukemia, Myelomonocytic, Chronic
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Leukemia-Lymphoma, Adult T-Cell
Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma.
Li-Fraumeni Syndrome
Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Liver Neoplasms
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Lung Neoplasms
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells.
ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells.
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients.
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.
Downregulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small cell lung cancer cells.
Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms.
Effects of Rad51 on survival of A549 cells.
EGFR Fusions as Novel Therapeutic Targets in Lung Cancer.
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.
High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells.
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Identification of cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers.
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy.
Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells.
KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma.
Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy.
Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells.
Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine.
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status.
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells.
Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells.
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.
The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.
Lymphatic Metastasis
Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.
BLM and RAD51 Genes Polymorphism and Susceptibility to Breast Cancer.
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
RAD51 protein expression is increased in canine mammary carcinomas.
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Lymphoma
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Lymphoma, B-Cell
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.
Lymphoma, Follicular
MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response.
Lymphoma, Mantle-Cell
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Macular Degeneration
Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.
Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study.
RAD51 gene is associated with advanced age-related macular degeneration in Chinese population.
Malaria
Synergistic Action between PfHsp90 Inhibitor and PfRad51 Inhibitor Induces Elevated DNA Damage Sensitivity in the Malaria Parasite.
Medulloblastoma
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.
Inhibition of ER? induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines.
Melanoma
Distinct genomic traits of acral and mucosal melanomas revealed by targeted mutational profiling.
Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance.
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?.
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
Targeting Rad51 as a strategy for the treatment of melanoma cells resistant to MAPK pathway inhibition.
The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma.
Mesothelioma
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Mesothelioma, Malignant
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Microcephaly
Microcephaly family protein MCPH1 stabilizes RAD51 filaments.
Movement Disorders
Abnormal subcortical activity in congenital mirror movement disorder with RAD51 mutation.
Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.
Multiple Myeloma
A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin.
Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma.
Myelodysplastic Syndromes
Association between RAD51 gene polymorphism (-135G/C) and susceptibility of myelodysplastic syndrome and acute leukemia: evidence based on a meta-analysis.
Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?
RAD51 and XRCC3 polymorphism frequency and risk of myelodysplastic syndromes.
Nasopharyngeal Carcinoma
Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression.
Rad51 Expression in Nasopharyngeal Carcinoma and Its Association with Tumor Reduction: A Preliminary Study in Indonesia.
Nasopharyngeal Neoplasms
RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.
Neoplasm Metastasis
Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.
BLM and RAD51 Genes Polymorphism and Susceptibility to Breast Cancer.
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis.
High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.
Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis.
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
RAD51 protein expression is increased in canine mammary carcinomas.
Rad51 supports triple negative breast cancer metastasis.
The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma.
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Neoplasms
135G>C and 172G>T polymorphism in the 5' untranslated region of RAD51 and sporadic endometrial cancer risk in Polish women.
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
?1-integrin impacts Rad51 stability and DNA double-strand break repair by homologous recombination.
A cell-penetrating antibody inhibits human RAD51 via direct binding.
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.
A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair.
A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks.
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue.
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
A novel 20-gene prognostic score in pancreatic adenocarcinoma.
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
A panel of tumor biomarkers to predict complete pathological response to neo-adjuvant treatment in Locally Advanced Rectal Cancer.
A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts.
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women.
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm.
Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.
AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.
Alternative transcript imbalance underlying breast cancer susceptibility in a family carrying PALB2 c.3201+5G>T.
An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
Analysis of 11 candidate genes in 849 adult patients with suspected hereditary cancer predisposition.
Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.
Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup.
Assessment of DNA Repair Gene Expressions in Vitrified Mouse Preantral Follicles.
Association between a functional variant in RAD51 gene's 3' untranslated region and its mRNA expression in lymphoblastoid cell lines.
Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer.
Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: A meta-analysis.
Association between the RAD51 135 G>C Polymorphism and Risk of Cancer: A Meta-Analysis of 19,068 Cases and 22,630 Controls.
Association of RAD51 with Homologous Recombination Deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial.
ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair.
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen.
BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer.
Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial.
BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity.
BRCA1 Gene Mutations in Breast Cancer Patients from Kerman Province, Iran.
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort.
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.
BRCA2-dependent and independent formation of RAD51 nuclear foci.
BRCA2-RAD51-DSS1 interplay examined from a microbial perspective.
BRCA2: a universal recombinase regulator.
c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.
Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes.
CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51.
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer.
Characterisation of the promoter region of the human DNA-repair gene Rad51.
Characterization of Gastric Cardia Tumors: Differences in Helicobacter pylori Strains and Genetic Polymorphisms.
Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH).
CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.
CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.
Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill.
Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation.
Clinical management of women with genomic BRCA1 and BRCA2 mutations.
Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer.
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.
Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer.
Cloning and sequencing full length of canine Brca2 and Rad51 cDNA.
Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress.
Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.
Common gene variants in RAD51, XRCC2 and XPD are not associated with clinical outcome in soft-tissue sarcoma patients.
Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with Mammary Tumors and histopathological analyses.
Common nonsense mutations in RAD52.
CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells.
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.
D-loop formation by Brh2 protein of Ustilago maydis.
DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors.
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines.
Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Design of BRC analogous peptides based on the complex BRC8-RAD51 and the preliminary study on the peptide structures.
Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor.
Dissecting the Recombination Mediator Activity of BRCA2 Using Biochemical Methods.
DNA damage response markers are differentially expressed in BRCA-mutated breast cancers.
DNA double-strand break repair signalling: the case of RAD51 post-translational regulation.
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil.
DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance.
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer.
Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.
Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.
DSS1 and ssDNA regulate oligomerization of BRCA2.
Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.
Effects of HsRad51 overexpression on cell proliferation, cell cycle progression, and apoptosis.
EGFR-Inhibition Enhances Apoptosis in Irradiated Human Head and Neck Xenograft Tumors Independent of Effects on DNA Repair.
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma.
Elevated levels of Rad51 recombination protein in tumor cells.
Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation.
Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51.
Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.
Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation.
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: Prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis.
Epigenomic Analysis of RAD51 ChIP-seq Data Reveals cis-regulatory Elements Associated with Autophagy in Cancer Cell Lines.
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.
Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer.
Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations.
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Expression, Purification, and Biochemical Evaluation of Human RAD51 Protein.
Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3).
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.
FIGNL1-containing protein complex is required for efficient homologous recombination repair.
FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA Repair Gene Rad51.
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas.
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila.
Functional evidence for Eme1 as a marker of cisplatin resistance.
Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development.
Fungal BRCA2 ortholog Brh2 brings 5' end strand invasion back on stage.
Gene expression in tumor-adjacent normal tissue is associated with recurrence in patients with rectal cancer treated with adjuvant chemoradiation.
Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls.
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.
Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors.
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
Glu-108 in Saccharomyces cerevisiae Rad51 Is Critical for DNA Damage-Induced Nuclear Function.
Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.
Haplotype and linkage disequilibrium architecture for human cancer-associated genes.
Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells.
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
High levels of wild-type BRCA2 suppress homologous recombination.
High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors.
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance.
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins.
Homologous recombination and its regulation.
Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells.
Homologous recombination, cancer and the 'RAD51 paradox'.
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.
Hypermethylation of RAD51L3 and XRCC2 genes to predict late toxicity in chemoradiotherapy-treated cervical cancer patients.
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Identification and characterization of human Rad51 inhibitors by screening of an existing drug library.
Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray.
Identification of DNA Repair Pathways that Affect the Survival of Ovarian Cancer Cells Treated with a PARP Inhibitor in a Novel Drug Combination.
Identification of miRNA modulators to PARP inhibitor response.
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells.
In vitro evidence for homologous recombinational repair in resistance to melphalan.
In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation.
In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin.
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Inhibiting homologous recombination by targeting RAD51 protein.
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Inhibition of filament formation of human Rad51 protein by a small peptide derived from the BRC-motif of the BRCA2 protein.
Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells.
Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis.
Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways.
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells.
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum.
Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats.
Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches.
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.
Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair.
Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells.
Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes.
Long time persistence of residual 53BP1/?-H2AX foci in human lymphocytes in relationship to apoptosis, chromatin condensation and biological dosimetry.
Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q12.3-13.1 and its relevance for prostate cancer.
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo.
Mechanism of Cediranib-Olaparib Combo Revealed.
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Meiotic recombination: an affair of two recombinases.
Methotrexate-mediated inhibition of RAD51 expression and homologous recombination in cancer cells.
miR-155 Over-expression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-prone DSB Repair.
miR-4429 sensitized cervical cancer cells to irradiation by targeting RAD51.
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition.
Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.
MRNIP is a replication fork protection factor.
Mutations in the RAD54 recombination gene in primary cancers.
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer.
Nonsense mutation at codon 63 of the BRCA1 gene in Japanese breast cancer patients.
Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients.
O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma.
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy.
Oleandrin induces DNA damage responses in cancer cells by suppressing the expression of Rad51.
Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis.
Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer.
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.
Overexpression of RAD51 occurs in aggressive prostatic cancer.
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.
Overexpression of SKP2 promotes the radiation resistance of esophageal squamous cell carcinoma.
Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker.
PALB2 (partner and localizer of BRCA2).
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations.
Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors.
Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas.
Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial.
Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers.
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer.
Polymorphisms in cancer susceptibility genes XRCC1, RAD51 and TP53 and the risk of breast cancer in Serbian women.
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer-a case control study.
Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51.
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.
Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9.
Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types.
Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
PRKC-? Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.
Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Prognostic Impact of DNA Repair Protein Expression in Non-Small Cell Lung Cancers Treated with Platinum-Based Chemotherapy and Subsequent Curative Lung Resection.
Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness.
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.
Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy.
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer.
Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.
RAD-ical New Insights into RAD51 Regulation.
RAD51 135G>C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women.
RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies.
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.
RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies.
RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.
Rad51 Expression in Nasopharyngeal Carcinoma and Its Association with Tumor Reduction: A Preliminary Study in Indonesia.
Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
RAD51 G135C gene polymorphism and risk of colorectal cancer in Kashmir.
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
RAD51 Gene Family Structure and Function.
RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland.
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor derived cells.
Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae.
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
RAD51 interconnects between DNA replication, DNA repair and immunity.
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma.
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability.
Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells.
RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination.
Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.
RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis.
Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation.
Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.
Rad51 protein expression and survival in patients with glioblastoma multiforme.
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.
Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin.
Rad51 supports triple negative breast cancer metastasis.
RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.
RAD51, genomic stability, and tumorigenesis.
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing.
RecA: Regulation and Mechanism of a Molecular Search Engine.
Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Regulation and pharmacological targeting of RAD51 in cancer.
Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?
Regulation of Rad51 promoter.
Relationship between Rad51 G135C and G172T variants and the susceptibility to cancer: a meta-analysis involving 54 case-control studies.
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond.
Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer.
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.
Role of NRP-1 in VEGF-VEGFR2-Independent Tumorigenesis.
Role of Rad51 and DNA repair in cancer: A molecular perspective.
Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy.
Rosiglitazone enhances radiosensitivity by inhibiting repair of DNA damage in cervical cancer cells.
Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families.
Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair.
Sensitization of tumor to (212)pb radioimmunotherapy by gemcitabine involves initial abrogation of g2 arrest and blocked DNA damage repair by interference with rad51.
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.
Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.
Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites.
Slug/?-Catenin-Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells.
Somatic mutations in early onset luminal breast cancer.
Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors.
Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2.
Structure of human BRCA2-RAD51 by molecular docking study.
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer.
Systematic Screen Identifies miRNAs that Target RAD51 and RAD51D to Enhance Chemosensitivity.
T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51.
Targeting homologous recombination by pharmacological inhibitors enhances the killing response of glioblastoma cells treated with alkylating drugs.
Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity.
Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51.
Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination.
Targeting PI3K and RAD51 in Barrett's Adenocarcinoma: Impact on DNA Damage Checkpoints, Expression Profile and Tumor Growth.
Targeting RAD51 enhances chemosensitivity of adult T?cell leukemia?lymphoma cells by reducing DNA double?strand break repair.
The ?-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing.
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.
The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland.
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.
The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer.
The BRCA2 gene product functionally interacts with p53 and RAD51.
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.
The canine RAD51 mutation leads to the attenuation of interaction with PALB2.
The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma.
The consequences of Rad51 overexpression for normal and tumor cells.
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma.
The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.
The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.
The potential value of the neutral comet assay and the expression of genes associated with DNA damage in assessing the radiosensitivity of tumor cells.
The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer.
The RAD51 gene family, genetic instability and cancer.
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
The relevance of prelamin A and RAD51 as molecular biomarkers in cervical cancer.
The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.
Therapeutic exploitation of tumor cell defects in homologous recombination.
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers.
TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.
Towards rational design of RAD51-targeting prodrugs: platinumIV-artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells.
TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro.
Trajectory and uniqueness of mutational signatures in yeast mutators.
Treatment of Nasopharyngeal Carcinoma Cells with the Histone-Deacetylase Inhibitor Abexinostat: Cooperative Effects with Cis-platin and Radiotherapy on Patient-Derived Xenografts.
Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors.
Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair.
Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
Use of the Rad51 promoter for targeted anti-cancer therapy.
Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy.
Using a fragment-based approach to target protein-protein interactions.
USP24 promotes drug resistance during cancer therapy.
Utilization of Rad51C promoter for transcriptional targeting of cancer cells.
Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy.
Variation in the RAD51 gene and familial breast cancer.
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer.
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.
XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients.
YM155 and BIRC5 downregulation induce genomic instability via autophagy-mediated ROS production and inhibition in DNA repair.
[Association of polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers]
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
[Hereditary breast carcinomas pathologist's perspective].
[Human RAD51 recombinase: the role in the cell cycle checkpoint and cellular survival]
Neoplasms, Squamous Cell
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
Neuroblastoma
Gene expression profiles and protein-protein interaction networks in neuroblastoma with MEIS2 depletion.
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
Neurofibromatoses
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Nijmegen Breakage Syndrome
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Obesity
Obesity alters phosphoramide mustard-induced ovarian DNA repair in mice.
Osteosarcoma
Berberine enhances the radiosensitivity of osteosarcoma by targeting Rad51 and epithelial-mesenchymal transition.
Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.
Genetic Association between ERCC2, NBN, RAD51 Gene Variants and Osteosarcoma Risk: a Systematic Review and Meta-Analysis
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Homologous Recombination Repair Polymorphisms and the Risk for Osteosarcoma.
Human Rad51 promotes mitochondrial DNA synthesis under conditions of increased replication stress.
Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells.
Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p.
Systematic Screen Identifies miRNAs that Target RAD51 and RAD51D to Enhance Chemosensitivity.
Ovarian Neoplasms
53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange.
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women.
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer.
Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51.
Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer.
Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.
Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer.
Clinicopathological values of NBS1 and DNA damage response genes in epithelial ovarian cancers.
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Cyclin D1 silencing impairs DNA double strand break repair, sensitizes BRCA1 wildtype ovarian cancer cells to olaparib.
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer.
Downregulation of the cancer susceptibility protein WRAP53? in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.
Emerging roles of lamins and DNA damage repair mechanisms in ovarian cancer.
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
Enhancing the sensitivity of ovarian cancer cells to olaparib via microRNA-20b-mediated cyclin D1 targeting.
Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types.
Germline mutation in the RAD51B gene confers predisposition to breast cancer.
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.
Identification of DNA Repair Pathways that Affect the Survival of Ovarian Cancer Cells Treated with a PARP Inhibitor in a Novel Drug Combination.
MicroRNA regulation of RAD51 in serous ovarian cancer modulates chemotherapy response.
miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis.
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells.
Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1 Interacting Genes.
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer.
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer.
RAD-ical New Insights into RAD51 Regulation.
RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer.
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
RAD51 Gene 135G/C polymorphism and ovarian cancer risk: a meta-analysis.
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
RAD51 paralog function in replicative DNA damage and tolerance.
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families.
Sulfolobus tokodaii RadA paralog, stRadC2, is involved in DNA recombination via interaction with RadA and Hjc.
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.
The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells.
The effect of RAD51 135 G>C and XRCC2 G>A (rs3218536) polymorphisms on ovarian cancer risk among Caucasians: a meta-analysis.
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
Therapy resistance on the RADar in ovarian cancer.
Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.
Pancreatic Neoplasms
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen.
DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma.
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
The association of changes in RAD51 and survivin expression levels with the proton beam sensitivity of Capan?1 and Panc?1 human pancreatic cancer cells.
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
The effects of SAHA on radiosensitivity in pancreatic cancer cells by inducing apoptosis and targeting RAD51.
[Expression of RAD51 and MAX in pancreatic cancer rats.]
Papilloma
Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.
Parathyroid Neoplasms
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Peutz-Jeghers Syndrome
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Precancerous Conditions
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.
Prostatic Neoplasms
Coordinate alterations in the expression of BRCA1, BRCA2, p300, and Rad51 in response to genotoxic and other stresses in human prostate cancer cells.
Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
Dynamic Regulation of Rad51 by E2F1 and p53 in Prostate Cancer Cells upon DrugInduced DNA Damage under Hypoxia.
Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer.
Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence.
Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q12.3-13.1 and its relevance for prostate cancer.
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.
Overexpression of RAD51 occurs in aggressive prostatic cancer.
Polymorphisms of homologous recombination RAD51, RAD51B, XRCC2, and XRCC3 genes and the risk of prostate cancer.
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy.
RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer.
Relationship between XPD, RAD51, and APEX1 DNA repair genotypes and prostate cancer risk in the male population of Rio de Janeiro, Brazil.
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.
STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
Synergistic loss of prostate cancer cell viability by coinhibition of HDAC and PARP.
Targeting c-MET to Enhance the Efficacy of Olaparib in Prostate Cancer.
The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
Pulmonary Arterial Hypertension
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
rada recombinase deficiency
Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence.
RAD51 deficiency disrupts the corticospinal lateralization of motor control.
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
Radiation Pneumonitis
Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.
Rectal Neoplasms
A panel of tumor biomarkers to predict complete pathological response to neo-adjuvant treatment in Locally Advanced Rectal Cancer.
Evaluation of relation of RAD51 and the effect of chemo-radiation therapy for advanced rectal cancer.
Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation.
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy.
Retinoblastoma
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis.
Rhabdomyosarcoma
Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors.
Sarcoma
Common gene variants in RAD51, XRCC2 and XPD are not associated with clinical outcome in soft-tissue sarcoma patients.
Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells.
Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines.
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Over-expression of RAD51 or RAD54 but not RAD51/4 enhances extra-chromosomal homologous recombination in the human sarcoma (HT-1080) cell line.
Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation.
Sarcoma, Synovial
Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor.
Seminoma
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Small Cell Lung Carcinoma
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Squamous Cell Carcinoma of Head and Neck
Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress.
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
p16INK4a Impairs Homologous Recombination-Mediated DNA Repair in Human Papillomavirus-Positive Head and Neck Tumors.
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population.
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism.
Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption.
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation.
Stomach Neoplasms
CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy.
DNA damage and repair in gastric cancer--a correlation with the hOGG1 and RAD51 genes polymorphisms.
Genetic polymorphisms of DNA repair pathways influence the response to chemotherapy and overall survival of gastric cancer.
Interferon regulatory factor-1 suppresses DNA damage response and reverses chemotherapy resistance by downregulating the expression of RAD51 in gastric cancer.
RAD51 G135C genetic polymorphism and their potential role in gastric cancer induced by Helicobacter pylori infection in Bhutan.
RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer.
The intricate interplay between MSI and polymorphisms of DNA repair enzymes in gastric cancer H.pylori associated.
Stomatitis
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis.
Telangiectasis
A UVR-Induced G2-Phase Checkpoint Response to ssDNA Gaps Produced by Replication Fork Bypass of Unrepaired Lesions Is Defective in Melanoma.
Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.
hMOF reduction enhances radiosensitivity through the homologous recombination pathway in non-small-cell lung cancer.
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Structural basis of homologous recombination.
Thyroid Cancer, Papillary
BRCA2 3'-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p.
RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Thyroid Neoplasms
Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk.
Increased risk of differentiated thyroid carcinoma with combined effects of homologous recombination repair gene polymorphisms in an Iranian population.
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
Triple Negative Breast Neoplasms
Association of RAD51 with Homologous Recombination Deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial.
Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation.
DDB2 depletion sensitizes triple-negative breast cancer cells to PARP inhibition by destabilizing Rad51.
Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51.
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.
RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women.
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
Rad51 supports triple negative breast cancer metastasis.
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.
Urinary Bladder Neoplasms
Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
Susceptibility of XPD and RAD51 Genetic Variants to Carcinoma of Urinary Bladder in North Indian Population.
Uterine Cervical Neoplasms
Association of RAD51 and XRCC2 Gene Polymorphisms with Cervical Cancer Risk in the Bangladeshi Women.
Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis.
miR-4429 sensitized cervical cancer cells to irradiation by targeting RAD51.
Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy.
Rosiglitazone enhances radiosensitivity by inhibiting repair of DNA damage in cervical cancer cells.
Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study.
T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51.
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma.
The relevance of prelamin A and RAD51 as molecular biomarkers in cervical cancer.
Use of the Rad51 promoter for targeted anti-cancer therapy.
Werner Syndrome
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Xeroderma Pigmentosum
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Susceptibility of XPD and RAD51 Genetic Variants to Carcinoma of Urinary Bladder in North Indian Population.
XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Gene Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis