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Information on EC 3.5.3.4 - allantoicase
for references in articles please use BRENDA:EC3.5.3.4
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EC Tree 3 Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.3 In linear amidines
3.5.3.4 allantoicase
IUBMB Comments
Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
- 3.5.3.4
- allantoinase
- purine
-
ureides
- uricase
- ureidoglycolate
-
uric
- urate
- xanthine
-
3.5.2.5
- mackerel
-
uricolytic
- pharmacology
showSynonyms
allantoicase, allantoate amidohydrolase, allantoate amidinohydrolase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AaALLC
Allantoate amidinohydrolase
allantoicase
Allantoine amidinohydrolase
-
-
-
-
ALLC
XAlc
Allantoate amidinohydrolase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
allantoate + H2O = (S)-ureidoglycolate + urea
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of linear amidines
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
allantoin degradation to ureidoglycolate I (urea producing)
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SYSTEMATIC NAME
IUBMB Comments
allantoate amidinohydrolase
Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.
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CAS REGISTRY NUMBER
COMMENTARY
9025-21-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(-)-ureidoglycolate + urea
allantoate + H2O
-
Substrates: -
Products: -
Products: -
r
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
Penicillium citreo-viride
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
(-)-ureidoglycolate
glyoxylate + urea
-
Substrates: -
Products: -
Products: -
?
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
Penicillium citreo-viride
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
?
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
?
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(-)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway
Products: -
Products: -
?
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway
Products: -
Products: -
?
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
allantoate + H2O
ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
?
allantoic acid + H2O
ureidoglycolate + urea
Substrates: alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway
Products: -
Products: -
?
allantoic acid + H2O
ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
allantoic acid + H2O
ureidoglycolate + urea
Substrates: alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway
Products: -
Products: -
?
allantoic acid + H2O
ureidoglycolate + urea
-
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
r
allantoate + H2O
(S)-ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
allantoic acid + H2O
ureidoglycolate + urea
Substrates: -
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
increased expression after blood meal at the end of digestion
-
additional information
-
increased expression after blood meal at the end of digestion
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
labelled uric acid metabolized to urea and excreted as nitrogenous waste through an uricolytic pathway, effect of intermediate products of the uricolytic pathway on urea synthesis analyzed by feeding mosquitoes with unlabeled intermediates, induced gene expression of allantoicase in response to blood meal feeding argues for a functional role of the uricolytic pathway in urea synthesis, significant increase in uric acid levels in whole-body extracts, reduction in labelled urea excretion
additional information
-
labelled uric acid metabolized to urea and excreted as nitrogenous waste through an uricolytic pathway, effect of intermediate products of the uricolytic pathway on urea synthesis analyzed by feeding mosquitoes with unlabeled intermediates, induced gene expression of allantoicase in response to blood meal feeding argues for a functional role of the uricolytic pathway in urea synthesis, significant increase in uric acid levels in whole-body extracts, reduction in labelled urea excretion
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2
8.3
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
feeding experiments, collection of feces and analysis by mass spectrometry
brenda
-
feeding experiments, collection of feces and analysis by mass spectrometry
-
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
downregulation of enzyme expression leads to a shortened cell cycle, a reduction in cell size relative to wild type cells and interrupted development
malfunction
-
downregulation of enzyme expression leads to a shortened cell cycle, a reduction in cell size relative to wild type cells and interrupted development
-
physiological function
normal functions of the enzyme include retarding cell division until a specific cell size is reached and coordinating the progression of development