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Requires Co2+ for maximal activity . N2-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine . This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 18.104.22.168 (arginine N-succinyltransferase), EC 22.214.171.124 (N-succinylarginine dihydrolase), EC 126.96.36.199 (acetylornithine transaminase), EC 188.8.131.52 (succinylglutamate-semialdehyde dehydrogenase) and EC 184.108.40.206 (succinylglutamate desuccinylase).
enzyme is part of the arginine succinyltransferase pathway, which is the major arginine and ornithine utilization pathway under aerobic conditions in Pseudomonas aeruginosa. The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively, and the aruF and aruG genes encode the subunits AruAI and AruAII of arginine and ornithine N2-succinyltransferases
only three enzymes of the ammonia-producing arginine succinyltransferase pathway can be measured in wild-type cells grown with ammonia as the sole nitrogen source: succinylarginine dihydrolase, succinylglutamate desuccinylase, and succinylornithine transaminase