Information on EC 3.5.1.5 - urease and Organism(s) Sporosarcina pasteurii and UniProt Accession P41020

(2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol

-

noncompetitive, 50% inhibition at 0.029 mM

(2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol

-

noncompetitive, 50% inhibition at 0.020 mM

(2S)-2-(dimethylamino)-3-mercaptopropan-1-ol

-

noncompetitive, 50% inhibition at 0.025 mM

(2S)-2-(dimethylamino)-3-methoxypropane-1-thiol

-

noncompetitive, 50% inhibition at 0.036 mM

(aminomethyl)methylphosphinic acid

-

(aminomethyl)phosphonic acid

-

(R)-4-methoxydalbergione

-

50% inhibition at 0.059 mM, isolated from roots of Ranunculus repens

669654

(R)-dalbergiophenol

-

50% inhibition at 0.025 mM, isolated from roots of Ranunculus repens

669654

([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid

-

2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione

-

2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione

-

2-thioxo-5-(2,3,4-trihydroxybenzylidene)dihydro-4,6(1H,5H)-pyrimidinedione

-

3,4,5-Trihydroxybenzoate

-

50% inhibition at 0.022 mM

669654

4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate

-

4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

-

4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione

-

4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one

-

competitive inhibition

4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one

-

uncompetitive inhibition

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one

-

competitive inhibition; uncompetitive inhibition

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one

-

uncompetitive inhibition

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one

-

competitive inhibition

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one

-

noncompetitive inhibition

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one

-

competitive inhibition, enzyme-ligand interaction analysis, structure, overview

4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one

-

uncompetitive inhibition, enzyme-ligand interaction analysis, structure, overview

4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one

-

competitive inhibition

5-(1,4-dihydro-9-anthracenylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione

-

5-(1H-indol-3-ylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2,4-dihydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2-aminobenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2-bromo-4,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2-hydroxy-3-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2-hydroxy-5-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2-methylbenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(2-thienylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(3,4-dihydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(3,4-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(3,5-dibromo-4-hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(3,5-dichloro-2-hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(3-hydroxy-4-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione

-

5-(4-bromo-2,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(4-ethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(4-hydroxy-3,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(4-hydroxy-3-iodo-5-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H) pyrimidinedione

-

5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione

-

5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione

-

5-(4-propoxyphenyl)-3-propyl-1,3,4-thiadiazole-2(3H)-thione

-

5-(4-pyridinylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-(4-[[4,6-dioxo-2-thioxotetrahydro-5(2H)pyrimidinylidene]methyl]-benzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione

-

5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione

-

5-benzyl-1,3,4-oxadiazole-2(3H)-thione

-

5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione

-

5-phenyl-1,3,4-oxadiazole-2(3H)-thione

-

5-phenyl-1,3,4-thiadiazole-2(3H)-thione

-

5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione

-

5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione

-

5-[(2-hydroxy-1-naphthyl)methylene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-[(5-methyl-2-furyl)methylene]-2-thioxodihydro-4,6(1H,5H)pyrimidinedione

-

5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione

-

5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione

-

5-[(6-bromo-4-chloro-2-oxo-2H-chromen-3-yl)methylene]-2-thioxodihydro 4,6(1H,5H)-pyrimidinedione

-

5-[(6-methyl-2-pyridinyl)methylene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione

-

5-[3-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione

-

5-[4(dimethylamino) benzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

-

5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione

-

5-[4-(methylsulfanyl)benzylidene]-2-thioxodihydro-4,6(1H,5H) pyrimidinedione

-

5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione

-

5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]thiadiazole-2-thione

-

7'-hydroxy-2,2'-dioxo-2H,2'H-6,8'-bichromen-7-yl alpha-L-mannopyranoside

-

7'-hydroxy-2,2'-dioxo-3'-[(2-oxo-2H-chromen-7-yl)oxy]-2H,2'H-8,8'-bichromen-7-yl alpha-D-glucopyranoside

-

7'-methoxy-2,2'-dioxo-3'-[(2-oxo-2H-chromen-7-yl)oxy]-2H,2'H-8,8'-bichromen-7-yl alpha-D-glucopyranoside

-

7-hydroxy-2,2'-dioxo-2H,2'H-6,8'-bichromen-7'-yl alpha-L-mannopyranoside

-

7-[(7-methoxy-2-oxo-2H-chromen-3-yl)oxy]-2-oxo-2H-chromen-6-yl alpha-D-glucopyranoside

-

8-hydroxy-3-[(6-hydroxy-2-oxo-2H-chromen-7-yl)oxy]-2-oxo-2H-chromen-7-yl beta-D-glucopyranoside

-

Acetohydroxamic acid

aminomethyl(P-methyl)phosphinic acid

-

catechol

irreversibly inactivates the enzyme with a complex radical-based autocatalytic multistep mechanism

754344

citrate

P41022; P41021; P41020

binding of the ligand to the active site involves stabilizing interactions, such as a carboxylate group that binds the nickel ions at the active site and several hydrogen bonds with the surrounding residues

734327

fluoride

-

two fluoride anions are coordinated to the Ni(II) ions in the active site, in terminal and bridging positions. One fluoride competitively binds to the Ni(II) ion proposed to coordinate urea in the initial step of the catalytic mechanism, while another fluoride uncompetitively substitutes the Ni(II)-bridging hydroxide, blocking its nucleophilic attack on urea. Kinetic studies on the fluoride-induced inhibition of urease, mixed competitive and predominant uncompetitive mechanism that increases by increasing the pH, and a lesser competitive inhibition that increases by lowering the pH, overview

734328

methyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate

-

methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

-

methyl 2-amino-4-methylthiophene-3-carboxylate

-

methyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate

-

methyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

-

methyl 2-[(methoxycarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

-

methyl 2-[bis(chlorocarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

-

methyl 2-[[(chloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

-

methyl 2-[[(chloromethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate

-

methyl 2-[[(dichloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

-

methyl 2-[[(methylsulfanyl)carbonothioyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

-

methyl[(methylamino)methyl]phosphinic acid

-

699444, 718558

N-(2,4-dichlorophenyl)-N'-(3,4-dimethylphenyl)thiourea

-

N-(2,4-dichlorophenyl)-N'-(3,5-dimethylphenyl)thiourea

-

N-(2,4-dichlorophenyl)-N'-(4-ethylphenyl)thiourea

-

N-(2,4-difluorophenyl)-N'-(2-iodophenyl)thiourea

-

N-(2,4-difluorophenyl)-N'-(3,4-dimethylphenyl)thiourea

-

N-(2,4-difluorophenyl)-N'-(3,5-dimethylphenyl)thiourea

-

N-(2,4-difluorophenyl)-N'-(4-iodophenyl)thiourea

-

N-(2,5-dimethylphenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(2,5-dimethylphenyl)-N'-[3-(trifluoromethyl)phenyl]thiourea

-

N-(2-bromophenyl)-N'-(4-ethylphenyl)thiourea

-

N-(2-bromophenyl)-N'-(5-chloro-2,4-dimethoxyphenyl)thiourea

-

N-(2-bromophenyl)-N'-[2-hydroperoxy-5-(trifluoromethyl)phenyl]thiourea

-

N-(2-bromophenyl)-N'-[3-(methylsulfanyl)phenyl]thiourea

-

N-(2-chloro-4,6-dimethoxyphenyl)-N'-(3-chlorophenyl)thiourea

-

N-(2-chloro-4,6-dimethoxyphenyl)-N'-[3-(trifluoromethyl)phenyl]thiourea

-

N-(2-iodophenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(3,4-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]thiourea

-

N-(3,4-dimethylphenyl)-N'-[2-hydroperoxy-5-(trifluoromethyl)phenyl]thiourea

-

N-(3,4-dimethylphenyl)-N'-[3-(trifluoromethyl)phenyl]thiourea

-

N-(3,5-dimethylphenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(3-chlorophenyl)-N'-(3-nitrophenyl)thiourea

-

N-(3-chlorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]thiourea

-

N-(3-methoxyphenyl)-N'-(3-nitrophenyl)thiourea

-

N-(4-bromophenyl)-N'-(2,4-difluorophenyl)thiourea

-

N-(4-bromophenyl)-N'-(3-chlorophenyl)thiourea

-

N-(4-bromophenyl)-N'-(3-fluorophenyl)thiourea

-

N-(4-bromophenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(4-chlorophenyl)-N'-[2-(trifluoromethyl)phenyl]thiourea

-

N-(4-ethylphenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(4-ethylphenyl)-N'-[3-(trifluoromethyl)phenyl]thiourea

-

N-(4-fluoro-3-nitrophenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(4-iodophenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(4-iodophenyl)-N'-[3-(trifluoromethyl)phenyl]thiourea

-

N-(5-chloro-2,4-dimethoxyphenyl)-N'-(3-methoxyphenyl)thiourea

-

N-(5-chloro-2,4-dimethoxyphenyl)-N'-[2-(trifluoromethyl)phenyl]thiourea

-

N-(5-chloro-2-methylphenyl)-N'-(3,4-dichlorophenyl)thiourea

-

N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid

-

N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid

-

N-dimethyl-L-cysteine

-

noncompetitive, 50% inhibition at 0.01 mM

N-dimethyl-S-methyl-L-cysteine

-

noncompetitive, 50% inhibition at 0.110 mM

N-glycyl-aminomethyl(P-methyl)phosphinic acid

-

N-[3-(methylsulfanyl)phenyl]-N'-[2-(trifluoromethyl)phenyl]thiourea

-

N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide

-

N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide

-

N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide

-

N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide

-

O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide

-

S-ethyl-L-cysteine

-

noncompetitive, 50% inhibition at 0.030 mM

sulfite

competitive inhibitor. The structure of the urease-sulfite complex, determined at 1.65 A resolution, shows the inhibitor bound to the dinuclear Ni(II) center of urease in a tridentate mode involving bonds between the two Ni(II) ions in the active site and all three oxygen atoms of the inhibitor

754342

Thiourea

[(acetylamino)methyl]methylphosphinic acid

-

[(acetylamino)methyl]phosphonic acid

-

[(benzylamino)methyl]methylphosphinic acid

-

[(dimethylamino)methyl]methylphosphinic acid

-

[(dimethylamino)methyl]phosphonic acid

-

[(methylamino)methyl]phosphonic acid

-

[[benzyl(methyl)amino]methyl]phosphonic acid

-

additional information

-

17.3 - 17.6

Urea

additional information

-

steady-state kinetics analysis

-

0.017 - 0.018

(2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol

0.002 - 0.055

(2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol

0.002 - 0.013

(2S)-2-(dimethylamino)-3-mercaptopropan-1-ol

0.002 - 0.019

(2S)-2-(dimethylamino)-3-methoxypropane-1-thiol

0.34

(aminomethyl)methylphosphinic acid

-

pH 7.0, 37°C

0.314

(aminomethyl)phosphonic acid

-

pH 7.0, 37°C

0.0175

([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid

-

0.02 - 0.03

2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione

0.002 - 0.005

2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione

0.04 - 0.29

4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate

0.29 - 0.31

4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

0.2 - 0.24

4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione

0.019

4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.0483

4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.0595 - 0.0636

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one

0.0681

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.0155

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.0513

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.0133

4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.053

4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.0275

4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one

-

pH 6.8, 30°C

0.13

5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione

0.15 - 0.16

5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione

0.05

5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione

0.002

5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione

0.06 - 0.19

5-(4-propoxyphenyl)-3-propyl-1,3,4-thiadiazole-2(3H)-thione

0.04 - 0.11

5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione

0.06 - 0.12

5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione

0.14 - 0.17

5-benzyl-1,3,4-oxadiazole-2(3H)-thione

0.09 - 0.1

5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione

0.16 - 0.19

5-phenyl-1,3,4-oxadiazole-2(3H)-thione

0.02 - 0.1

5-phenyl-1,3,4-thiadiazole-2(3H)-thione

0.09

5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione

0.11

5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione

0.005

5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione

0.005 - 0.008

5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione

0.006 - 0.01

5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione

0.09 - 0.16

5-[3-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione

0.69 - 0.85

5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione

0.23

5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione

0.15 - 0.25

5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]thiadiazole-2-thione

0.34

aminomethyl(P-methyl)phosphinic acid

-

0.018

methyl[(methylamino)methyl]phosphinic acid

0.00017

N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid

-

0.043

N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid

-

0.002 - 0.009

N-dimethyl-L-cysteine

0.006 - 0.008

N-dimethyl-S-methyl-L-cysteine

0.021

N-glycyl-aminomethyl(P-methyl)phosphinic acid

-

0.215

N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide

-

0.037

N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide

-

0.12

N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide

-

0.135

N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide

-

0.025

O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide

-

0.011 - 0.014

S-ethyl-L-cysteine

0.19

sulfite

pH 7.0, 25°C

754342

0.095

[(acetylamino)methyl]methylphosphinic acid

-

pH 7.0, 37°C

0.148

[(acetylamino)methyl]phosphonic acid

-

pH 7.0, 37°C

0.072

[(benzylamino)methyl]methylphosphinic acid

-

pH 7.0, 37°C

0.00062

[(dimethylamino)methyl]methylphosphinic acid

-

pH 7.0, 37°C

0.013

[(dimethylamino)methyl]phosphonic acid

-

pH 7.0, 37°C

0.07

[(methylamino)methyl]phosphonic acid

-

pH 7.0, 37°C

0.115

[[benzyl(methyl)amino]methyl]phosphonic acid

-

pH 7.0, 37°C

additional information

-

inhibitionkinetics analysis

-

1.1

(aminomethyl)methylphosphinic acid

Sporosarcina pasteurii

-

pH 7.0, 37°C

0.7

(aminomethyl)phosphonic acid

Sporosarcina pasteurii

-

pH 7.0, 37°C

0.112

([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid

Sporosarcina pasteurii

-