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Information on EC 3.5.1.46 - 6-aminohexanoate-oligomer exohydrolase

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IUBMB Comments
The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2--20 by exo-type cleavage, removing residues sequentially from the N-terminus. Activity decreases with the increase of the polymerization number of the oligomer. cf. EC 3.5.1.117, 6-aminohexanoate-oligomer endohydrolase and EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase.
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The enzyme appears in viruses and cellular organisms
Synonyms
6-aminohexanoate oligomer hydrolase, 6-aminohexanoate-dimer hydrolase, 6-aminohexanoic acid oligomer hydrolase, EII, EII', Hyb-24DN, N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase, NylB, NylCA, NylCK, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate
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[N-(6-aminohexanoyl)]n + H2O = [N-(6-aminohexanoyl)]n-1 + 6-aminohexanoate
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