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Information on EC 3.5.1.46 - 6-aminohexanoate-oligomer exohydrolase

for references in articles please use BRENDA:EC3.5.1.46

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IUBMB Comments

The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus. Activity decreases with the increase of the polymerization number of the oligomer. cf. EC 3.5.1.117, 6-aminohexanoate-oligomer endohydrolase and EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
6-aminohexanoate-dimer hydrolase, hyb-24, nylon oligomer hydrolase, 6-aminohexanoate dimer hydrolase, hyb-24dn, 6-aminohexanoate oligomer hydrolase, nylcp2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate
show the reaction diagram
[N-(6-aminohexanoyl)]n + H2O = [N-(6-aminohexanoyl)]n-1 + 6-aminohexanoate
show the reaction diagram
(1)
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