Ligand 6-aminohexanoate

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Basic Ligand Information

Molecular Structure
Picture of 6-aminohexanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13NO2
6-aminohexanoate
SLXKOJJOQWFEFD-UHFFFAOYSA-N
Synonyms:
6-amino-1-hexanoic acid, 6-amino-hexanoic acid, 6-amino-n-caproate, 6-amino-n-hexanoate, 6-amino-n-hexanoic acid, 6-aminocaproate, 6-aminocaproic acid, 6-aminohexanoic acid, epsilon-amino-caproic acid, epsilon-amino-n-caproate, epsilon-amino-n-caproic acid, epsilon-aminocaproate, epsilon-amino caproic acid, epsilon-aminocaproic acid, epsilon-aminohexanoate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-aminocaproic acid + 2-oxoglutarate + O2 = D-2-hydroxy-6-aminocaproic acid + succinate + CO2
show the reaction diagram
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Z-Gln-Gly + 6-aminocaproic acid = ?
show the reaction diagram
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thiamine + 6-aminohexanoic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 6-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]hexanoic acid
show the reaction diagram
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6-aminohexanoate + 2-oxoglutarate = L-glutamate + 6-oxohexanoate
show the reaction diagram
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2-oxoglutarate + 6-aminohexanoate = glutamate + 6-oxohexanoate
show the reaction diagram
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epsilon-amino-n-caproate + 4,5-dioxopentanoate = 5-aminolevulinate + 6-oxo-n-hexanoate
show the reaction diagram
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6-aminohexanoate + 2-oxoglutarate = adipic semialdehyde + L-glutamate
show the reaction diagram
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benzoyl-Arg ethyl ester + 6-amino-hexanoic acid = ethanol + benzoyl-Arg-6-amino-hexanoic acid
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (147 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-oxohexanoate + L-alanine = 6-aminohexanoate + pyruvate
show the reaction diagram
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6-aminohexanamide + H2O = 6-aminohexanoate + NH3
show the reaction diagram
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6-acetamidohexanoate + H2O = acetate + 6-aminohexanoate
show the reaction diagram
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6-guanidinocaproate + H2O = 6-aminohexanoate + urea
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
marginally increases the refolding yield in the presence of Arg, and it is unable to replace Arg in promoting a high refolding yield
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5 mM, 2.32fold activation
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Inhibitor in Enzyme-catalyzed Reactions (48 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor toward lysine
-
inhibition 20% by 10 mM 6-amino-n-caproate
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0.2 mM, 72% inhibition
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5 mM, 35% inhibition
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70% inhibition at 100 mM
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20 mM, 10% inhibition of amidolytic activity
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caseinolytic activity
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Ki: 0.05 mM
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ATP-diphosphate exchange reaction
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slight
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3D Structure of Enzyme-Ligand-Complex (PDB) (245 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
38
-
-

Ki Value (10 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.26
-
-
300
-
-
0.9
-
pH 7.4
0.05
-
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References & Links

Links to other databases for 6-aminohexanoate

ChEBI
PubChem
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PubChem